Carbapenem-resistant Acinetobacter baumannii in intensive care unit patients: risk factors for acquisition, infection and their consequences

E. G. Playford, J. C. Craig, J. R. Iredell

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Summary

A retrospective case–control study was performed to assess risk factors and the clinical and economic consequences associated with acquisition of carbapenem-resistant Acinetobacter baumannii (CR-AB) in an intensive care unit (ICU) over a 24-month period. CR-AB was acquired by 64 of 1431 ICU admissions; each was matched with two controls. Risk factors associated with CR-AB acquisition included ICU-wide variables, such as ‘colonization pressure’ (the prevalence of ICU colonized patients) and ICU antibiotic use over the preceding three months, as well as patient-related variables. Among colonized patients, risk factors for CR-AB infection included transfusion and ‘colonization density’ (the proportion of body sites colonized with CR-AB). CR-AB infection was independently associated with increased hospital mortality [mortality difference: 20%; 95% confidence interval (CI): 1–40%], prolonged ICU stay (median length of stay difference: 15 days; 95% CI: 9–21 days) and prolonged hospital stay (30 days, 11–38 days) compared with matched controls.
Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalJOURNAL OF HOSPITAL INFECTION
Volume65
Issue number3
Publication statusPublished - Mar 2007
Externally publishedYes

Keywords

  • Acinetobacter
  • Acinetobacter infections
  • Mortality
  • Length of stay
  • Case-control study
  • Cross infection
  • Intensive care unit

Fingerprint Dive into the research topics of 'Carbapenem-resistant Acinetobacter baumannii in intensive care unit patients: risk factors for acquisition, infection and their consequences'. Together they form a unique fingerprint.

  • Cite this