Cardio-Renal Syndrome: New Perspective in Diagnostics

Pupalan Iyngkaran, Hans-Gerhard Schneider, P Devarajan, Nagesh Anavekar, Henry Krum, Claudio Ronco

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)


    Chronic heart failure and chronic renal failure are at epidemic proportions. These patients have significantly altered cardiac, renal, and all-cause outcomes. Much of the current research has focused on treating these individual organs in isolation. Although there are positive data on outcomes with neurohormonal modulation, they, however, remain underused. At present, data lacks for novel treatment options, while evidence continues to point at significantly worsened prognosis. Current diagnostic tools that detect acute changes in renal function or renal injury appear retrospective, which often hinder meaningful diagnostic and therapeutic decisions. This review is aimed at exploring the importance of accurate assessment of renal function for the heart failure patient by providing a synopsis on cardio-renal physiology and establishing the possibility of novel approaches in bridging the divide.

    Original languageEnglish
    Pages (from-to)3-17
    Number of pages15
    Issue number1
    Publication statusPublished - Jan 2012


    • Biomarkers
    • Creatinine
    • Heart failure
    • Physiology
    • Renal failure


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