Cardioactive neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) and novel related peptides are encoded in multiple copies by a single gene in the snail Lymnaea stagnalis

A. Linacre, Elaine Kellett, S. Saunders, K. Bright, P. R. Benjamin, J. F. Burke

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

The neuropeptide Phe-Met-Arg-Phe-NH2 (FMRFamide) is a potent cardioactive neuropeptide in Lymnaea stagnalis. Isolation and sequencing of 2 cDNAs and a genomic clone shows that a single gene encodes a precursor protein which contains 9 copies of the FMRFamide peptide, 2 copies of the related peptide Phe-Leu-Arg-Phe-NH2 (FLRFamide), and single copies of the putative pentapeptides Gln-Phe-Tyr-Arg-Ile-NH2 (EFLRIamide). The gene is transcribed in the CNS and gives rise to a single RNA of 1.7 kb in size. The organization of the Lymnaea gene is significant with respect to the evolution of FMRFamide and related peptides in other organisms.

Original languageEnglish
Pages (from-to)412-419
Number of pages8
JournalJournal of Neuroscience
Volume10
Issue number2
DOIs
Publication statusPublished - 1 Feb 1990
Externally publishedYes

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