Cardiopulmonary Bypass Circuit and the Brain

Michael Borger, George Djaiani, Robert Baker

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    Credit for the development of modern day cardiopulmonary bypass (CPB) is usually given to John Gibbons, who produced a functional heart-lung machine at the Mayo Clinic in the early 1950s.1 The development of the CPB circuit and the field of perfusion in general have been instrumental in the advancement of cardiac surgery over the last 5 decades. However, important neurologic complications were described shortly after the widespread adoption of CPB.2,3 Such central nervous system complications range from subclinical cognitive dysfunction to delirium, to focal stroke, to coma and/or death. An ever-increasing number of clinical and basic research investigations have focused on the impact of CPB on neurologic complications since the 1980s.4-12

    Original languageEnglish
    Title of host publicationBrain Protection in Cardiac Surgery
    Number of pages8
    ISBN (Print)9781849962926
    Publication statusPublished - 2011


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