Carotid and cardiopulmonary chemoreceptor activity increases hippocampal theta rhythm in conscious rabbits

Ying Hui Yu, W. W. Blessing

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    We have examined whether activation of carotid artery chemoreceptors causes alerting in conscious rabbits. Injection of phenylbiguanide (a 5- hydroxytryptamine3-receptor agonist) into the common carotid artery of conscious rabbits increased the proportion of theta rhythm in the hippocampal EEG, commencing in the first 5-s epoch after the injection. Intravenous injection of phenylbiguanide also increased the proportion of theta rhythm in the hippocampal electroencephalogram (EEG), but the onset of the change was not until the second 5-s epoch following injection. Injection of Ringer solution, either into the common carotid artery or into the marginal ear vein, did not affect the hippocampal EEG. Results suggest that phenylbiguanide-mediated activation of carotid and cardiopulmonary chemoreceptor afferents alerts the animal, as assessed by induction of theta rhythm in the hippocampal EEG. This alerting response presumably reflects the action of neural inputs that enter the brain with the carotid sinus nerve at the level of the medulla oblongata.

    Original languageEnglish
    Pages (from-to)R973-R979
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume278
    Issue number4
    DOIs
    Publication statusPublished - Apr 2000

    Keywords

    • 5-hydroxytryptamine receptors
    • Arousal/orientation response
    • Carotid body
    • Carotid sinus nerve
    • Electroencephalogram
    • Sudden infant death syndrome

    Fingerprint Dive into the research topics of 'Carotid and cardiopulmonary chemoreceptor activity increases hippocampal theta rhythm in conscious rabbits'. Together they form a unique fingerprint.

  • Cite this