Caspase-1 as a regulatory molecule of lipid metabolism

Meseret Derbew Molla; Birhanu Ayelign; Gashaw Dessie; Zeleke Geto; Tesfahun Dessale Admasu

doi:10.1186/s12944-020-01220-y

Caspase-1 as a regulatory molecule of lipid metabolism

Meseret Derbew Molla, Birhanu Ayelign, Gashaw Dessie, Zeleke Geto, Tesfahun Dessale Admasu

Research output: Contribution to journal › Review article › peer-review

41 Citations (Scopus)

1 Downloads (Pure)

Abstract

Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.

Original language	English
Article number	34
Number of pages	7
Journal	Lipids in Health and Disease
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12944-020-01220-y
Publication status	Published - Dec 2020
Externally published	Yes

Keywords

Caspase-1
Inflammasome
Lipid metabolism
Transcriptional factors

Access to Document

10.1186/s12944-020-01220-yLicence: CC BY

Published versionFinal published version, 767 KBLicence: CC BY

Cite this

@article{1f90e567d0ba441e8cbb6aa3bc00a9a3,

title = "Caspase-1 as a regulatory molecule of lipid metabolism",

abstract = "Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.",

keywords = "Caspase-1, Inflammasome, Lipid metabolism, Transcriptional factors",

author = "Molla, {Meseret Derbew} and Birhanu Ayelign and Gashaw Dessie and Zeleke Geto and Admasu, {Tesfahun Dessale}",

year = "2020",

month = dec,

doi = "10.1186/s12944-020-01220-y",

language = "English",

volume = "19",

journal = "Lipids in Health and Disease",

publisher = "BioMed Central Ltd.",

number = "1",

}

TY - JOUR

T1 - Caspase-1 as a regulatory molecule of lipid metabolism

AU - Molla, Meseret Derbew

AU - Ayelign, Birhanu

AU - Dessie, Gashaw

AU - Geto, Zeleke

AU - Admasu, Tesfahun Dessale

PY - 2020/12

Y1 - 2020/12

N2 - Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.

AB - Caspase-1 is an evolutionarily conserved inflammatory mediated enzyme that cleaves and activates inflammatory cytokines. It can be activated through the assembly of inflammasome and its major effect is to activate the pro-inflammatory cytokines; interleukin 1β (IL-1β) and interluekine-18 (IL-18). In addition to IL-1β and IL-8, several lines of evidence showed that caspase-1 targets the substrates that are involved in different metabolic pathways, including lipid metabolism. Caspase-1 regulates lipid metabolism through cytokine dependent or cytokine independent regulation of genes that involved in lipid metabolism and its regulation. To date, there are several reports on the role of caspase-1 in lipid metabolism. Therefore, this review is aimed to summarize the role of caspase-1 in lipid metabolism and its regulation.

KW - Caspase-1

KW - Inflammasome

KW - Lipid metabolism

KW - Transcriptional factors

UR - http://www.scopus.com/inward/record.url?scp=85081248268&partnerID=8YFLogxK

U2 - 10.1186/s12944-020-01220-y

DO - 10.1186/s12944-020-01220-y

M3 - Review article

C2 - 32143623

AN - SCOPUS:85081248268

VL - 19

JO - Lipids in Health and Disease

JF - Lipids in Health and Disease

IS - 1

M1 - 34

ER -

Caspase-1 as a regulatory molecule of lipid metabolism

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this