Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis

Clement Menuet, Charles Sevigny, Angela Connelly, Jaspreet Bassi, Nikola Jancovski, David Williams, Colin Anderson, Ida Llewellyn-Smith, Angelina Fong, Andrew Allen

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    16 Citations (Scopus)

    Abstract

    Brainstem catecholaminergic neurons play key roles in the autonomic, neuroendocrine, and behavioral responses to glucoprivation, yet the functions of the individual groups are not fully understood. Adrenergic C3 neurons project widely throughout the brain, including densely to sympathetic preganglionic neurons in the spinal cord, yet their function is completely unknown. Here we demonstrate in rats that optogenetic stimulation of C3 neurons induces sympathoexcitatory, cardiovasomotor functions. These neurons are activated by glucoprivation, but unlike the C1 cell group, not by hypotension. The cardiovascular activation induced by C3 neurons is less than that induced by optogenetic stimulation of C1 neurons; however, combined stimulation produces additive sympathoexcitatory and cardiovascular effects. The varicose axons of C3 neurons largely overlap with those of C1 neurons in the region of sympathetic preganglionic neurons in the spinal cord; however, regional differences point to effects on different sympathetic outflows. These studies definitively demonstrate the first known function of C3 neurons as unique cardiovasomotor stimulatory cells, embedded in the brainstem networks regulating cardiorespiratory activity and the response to glucoprivation.

    Original languageEnglish
    Pages (from-to)15110-15122
    Number of pages13
    JournalJournal of Neuroscience
    Volume34
    Issue number45
    DOIs
    Publication statusPublished - 5 Nov 2014

    Keywords

    • Channelrhodopsin
    • Glucoprivation
    • Rostral ventrolateral medulla
    • Sympathetic nervous system

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  • Cite this

    Menuet, C., Sevigny, C., Connelly, A., Bassi, J., Jancovski, N., Williams, D., Anderson, C., Llewellyn-Smith, I., Fong, A., & Allen, A. (2014). Catecholaminergic C3 neurons are sympathoexcitatory and involved in glucose homeostasis. Journal of Neuroscience, 34(45), 15110-15122. https://doi.org/10.1523/JNEUROSCI.3179-14.2014