Catecholamines and the covert orientation of attention in humans

C. R. Clark, G. M. Geffen, L. B. Geffen

    Research output: Contribution to journalArticlepeer-review

    173 Citations (Scopus)

    Abstract

    The role of brain catecholamines in covert orienting was tested in normal subjects using a cued reaction time paradigm which measures the directional engagement, disengagement and movement of attention. Droperidol and clonidine were administered intravenously to suppress central dopamine and noradrenaline transmission. Both drugs produced reductions in the cost of invalid cueing without change in the benefit of valid cueing suggesting that both noradrenaline and dopamine are involved in facilitating the disengagement of attention. These results are relevant to the slowed disengagement observed with parietal lesions in monkeys and humans since this region of the cortex associated with visuospatial analysis receives a dense innervation by both dopamine and noradrenaline projections in primates.

    Original languageEnglish
    Pages (from-to)131-139
    Number of pages9
    JournalNeuropsychologia
    Volume27
    Issue number2
    DOIs
    Publication statusPublished - 1989

    Fingerprint

    Dive into the research topics of 'Catecholamines and the covert orientation of attention in humans'. Together they form a unique fingerprint.

    Cite this