Cefdinir versus amoxicillin/clavulanic acid in the treatment of suppurative acute otitis media in children

M. Adler, P. J. McDonald, U. Trostmann, C. Keyserling, K. Tack

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

An investigator-blinded, randomized, multicenter study was conducted to compare the efficacy and safety of cefdinir and amoxicillin/clavulanate (amoxicillin/CA) in the treatment of pediatric patients with acute suppurative otitis media. Patients 6 months to 12 years of age were randomized in a 1:1:1 ratio to receive cefdinir 14 mg/kg once-daily, cefdinir 7 mg/kg b.i.d., or amoxicillin/CA 13.3 mg/kg t.i.d. Test-of-cure was determined 11 to 16 days post therapy. Of the 752 patients who entered the study, 665 (88%) completed treatment and 595 (79%) were evaluable. Response rates in the three treatment groups were similar. Overall rates of adverse events were statistically lower in the cefdinir once-daily group than in the amoxicillin/CA group. Diarrhea was the most common adverse event in all treatment groups. Cefdinir given either once-daily or twice daily is a safe and effective treatment for pediatric patients with acute suppurative otitis media.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 1997
Externally publishedYes

Keywords

  • otitis media
  • children

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