Cellular immune activation in Sardinian middle-aged, older adults and centenarians

Salvatore Sotgia, Angelo Zinellu, Arduino Mangoni, Roberta Serra, Gianfranco Pintus, Calogero Caruso, Luca Deiana, Ciriaco Carru

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)


    In addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum concentrations of this biomarker of systemic immune and inflammation activation, were measured in a small cohort of Sardinian middle-aged, older adults and centenarians. There was a significant positive correlation between neopterin concentrations and age with the subjects in the 95-year-old group with the highest values. Notably, the group of centenarians had neopterin values comparable to those of 80- and 90-year-old groups, and significantly lower than that of 95-year-old group. This suggests a decreased monocyte/macrophage-mediated immune activation and an apparently preserved immune status in centenarians.

    Original languageEnglish
    Pages (from-to)133-137
    Number of pages5
    Publication statusPublished - 1 Dec 2017


    • Aging
    • Centenarians
    • Cytokines
    • Immunosenescence
    • Inflammaging
    • Longevity
    • Pteridines


    Dive into the research topics of 'Cellular immune activation in Sardinian middle-aged, older adults and centenarians'. Together they form a unique fingerprint.

    Cite this