Ceramide evokes an apoptotic integrated stress response in Acute Myeloid Leukemia

Jason Powell, Alexander Lewis, Melinda Tea, Thao Nguyen, Craig Wallington-Beddoe, Dovile Anderson, Darren Creek, Richard D'Andrea, David Ross, Daniel Thomas, Stuart Pitson

Research output: Contribution to journalMeeting Abstractpeer-review


Increases in the pro-apoptotic lipid ceramide are thought to contribute to the efficacy of many anti-cancer agents used in the clinic. How the tumour suppressive activity of ceramide is exerted, however, remains poorly understood. Sphingosine kinase 1 (SPHK1) is a promoter of oncogenic signalling by the production of sphingosine-1-phosphate at the expense of pro-apoptotic lipids, ceramide and sphingosine.
Original languageEnglish
Pages (from-to)S83
Number of pages1
JournalExperimental Hematology
Issue numberSupplement
Publication statusPublished - Aug 2019
Externally publishedYes
Event48th ISEH Annual Scientific Meeting - Brisbane Convention & Exhibition Centre, Brisbane, Australia
Duration: 22 Aug 201925 Aug 2019


  • ceramide
  • Apoptotic
  • stress response
  • Acute myeloid leukemia
  • sphingosine kinase 1
  • protein kinase R


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