Ceramide evokes an apoptotic integrated stress response in Acute Myeloid Leukemia

Jason Powell; Alexander Lewis; Melinda Tea; Thao Nguyen; Craig Wallington-Beddoe; Dovile Anderson; Darren Creek; Richard D'Andrea; David Ross; Daniel Thomas; Stuart Pitson

doi:10.1016/j.exphem.2019.06.424

Ceramide evokes an apoptotic integrated stress response in Acute Myeloid Leukemia

Jason Powell, Alexander Lewis, Melinda Tea, Thao Nguyen, Craig Wallington-Beddoe, Dovile Anderson, Darren Creek, Richard D'Andrea, David Ross, Daniel Thomas, Stuart Pitson

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Increases in the pro-apoptotic lipid ceramide are thought to contribute to the efficacy of many anti-cancer agents used in the clinic. How the tumour suppressive activity of ceramide is exerted, however, remains poorly understood. Sphingosine kinase 1 (SPHK1) is a promoter of oncogenic signalling by the production of sphingosine-1-phosphate at the expense of pro-apoptotic lipids, ceramide and sphingosine.

Original language	English
Pages (from-to)	S83
Number of pages	1
Journal	Experimental Hematology
Volume	76
Issue number	Supplement
DOIs	https://doi.org/10.1016/j.exphem.2019.06.424
Publication status	Published - Aug 2019
Externally published	Yes
Event	48th ISEH Annual Scientific Meeting - Brisbane Convention & Exhibition Centre, Brisbane, Australia Duration: 22 Aug 2019 → 25 Aug 2019

Keywords

ceramide
Apoptotic
stress response
Acute myeloid leukemia
sphingosine kinase 1
protein kinase R

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.exphem.2019.06.424Licence: In Copyright

Cite this

@article{3b01756f04934c70b45daf2a6f784d2e,

title = "Ceramide evokes an apoptotic integrated stress response in Acute Myeloid Leukemia",

abstract = "Increases in the pro-apoptotic lipid ceramide are thought to contribute to the efficacy of many anti-cancer agents used in the clinic. How the tumour suppressive activity of ceramide is exerted, however, remains poorly understood. Sphingosine kinase 1 (SPHK1) is a promoter of oncogenic signalling by the production of sphingosine-1-phosphate at the expense of pro-apoptotic lipids, ceramide and sphingosine. ",

keywords = "ceramide, Apoptotic, stress response, Acute myeloid leukemia, sphingosine kinase 1, protein kinase R",

author = "Jason Powell and Alexander Lewis and Melinda Tea and Thao Nguyen and Craig Wallington-Beddoe and Dovile Anderson and Darren Creek and Richard D'Andrea and David Ross and Daniel Thomas and Stuart Pitson",

year = "2019",

month = aug,

doi = "10.1016/j.exphem.2019.06.424",

language = "English",

volume = "76",

pages = "S83",

journal = "Experimental Hematology",

issn = "0301-472X",

publisher = "Elsevier Science Inc",

number = "Supplement",

note = "48th ISEH Annual Scientific Meeting, ISEH Brisbane 2019 ; Conference date: 22-08-2019 Through 25-08-2019",

}

TY - JOUR

T1 - Ceramide evokes an apoptotic integrated stress response in Acute Myeloid Leukemia

AU - Powell, Jason

AU - Lewis, Alexander

AU - Tea, Melinda

AU - Nguyen, Thao

AU - Wallington-Beddoe, Craig

AU - Anderson, Dovile

AU - Creek, Darren

AU - D'Andrea, Richard

AU - Ross, David

AU - Thomas, Daniel

AU - Pitson, Stuart

PY - 2019/8

Y1 - 2019/8

N2 - Increases in the pro-apoptotic lipid ceramide are thought to contribute to the efficacy of many anti-cancer agents used in the clinic. How the tumour suppressive activity of ceramide is exerted, however, remains poorly understood. Sphingosine kinase 1 (SPHK1) is a promoter of oncogenic signalling by the production of sphingosine-1-phosphate at the expense of pro-apoptotic lipids, ceramide and sphingosine.

AB - Increases in the pro-apoptotic lipid ceramide are thought to contribute to the efficacy of many anti-cancer agents used in the clinic. How the tumour suppressive activity of ceramide is exerted, however, remains poorly understood. Sphingosine kinase 1 (SPHK1) is a promoter of oncogenic signalling by the production of sphingosine-1-phosphate at the expense of pro-apoptotic lipids, ceramide and sphingosine.

KW - ceramide

KW - Apoptotic

KW - stress response

KW - Acute myeloid leukemia

KW - sphingosine kinase 1

KW - protein kinase R

U2 - 10.1016/j.exphem.2019.06.424

DO - 10.1016/j.exphem.2019.06.424

M3 - Meeting Abstract

SN - 0301-472X

VL - 76

SP - S83

JO - Experimental Hematology

JF - Experimental Hematology

IS - Supplement

T2 - 48th ISEH Annual Scientific Meeting

Y2 - 22 August 2019 through 25 August 2019

ER -

Ceramide evokes an apoptotic integrated stress response in Acute Myeloid Leukemia

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this