Cerebrovascular function and cognition in childhood: A systematic review of transcranial doppler studies

Mireille Bakker, Jessica Hofmann, Owen Churches, Nicholas Badcock, Mark Kohler, Hannah Keage

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Background:The contribution of cerebrovascular function to cognitive performance is gaining increased attention. Transcranial doppler (TCD) is portable, reliable, inexpensive and extremely well tolerated by young and clinical samples. It enables measurement of blood flow velocity in major cerebral arteries at rest and during cognitive tasks.Methods:We systematically reviewed evidence for associations between cognitive performance and cerebrovascular function in children (0-18 years), as measured using TCD. A total of 2778 articles were retrieved from PsychInfo, Pubmed, and EMBASE searches and 25 relevant articles were identified.Results:Most studies investigated clinical groups, where decreased blood flow velocities in infants were associated with poor neurological functioning, and increased blood flow velocities in children with Sickle cell disease were typically associated with cognitive impairment and lower intelligence. Studies were also identified assessing autistic behaviour, mental retardation and sleep disordered breathing. In healthy children, the majority of studies reported cognitive processing produced lateralised changes in blood flow velocities however these physiological responses did not appear to correlate with behavioural cognitive performance.Conclusion:Poor cognitive performance appears to be associated with decreased blood flow velocities in premature infants, and increased velocities in Sickle cell disease children using TCD methods. However knowledge in healthy samples is relatively limited. The technique is well tolerated by children, is portable and inexpensive. It therefore stands to make a valuable contribution to knowledge regarding the underlying functional biology of cognitive performance in childhood.

    Original languageEnglish
    Article number43
    Pages (from-to)Article 43
    Number of pages12
    JournalBMC Neurology
    Volume14
    Issue number1
    DOIs
    Publication statusPublished - 6 Mar 2014

    Keywords

    • Adolescents
    • Cerebrovascular
    • Children
    • Cognition
    • Infants
    • Transcranial doppler

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    Bakker, M., Hofmann, J., Churches, O., Badcock, N., Kohler, M., & Keage, H. (2014). Cerebrovascular function and cognition in childhood: A systematic review of transcranial doppler studies. BMC Neurology, 14(1), Article 43. [43]. https://doi.org/10.1186/1471-2377-14-43