TY - JOUR
T1 - Cessation of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
AU - Middeldorp, Melissa E.
AU - Gupta, Aashray
AU - Elliott, Adrian
AU - Kadhim, Kadhim
AU - Thiyagarajah, Anand
AU - Gallagher, Celine
AU - Hendriks, Jeroen
AU - Linz, Dominik
AU - Emami, Mehrdad
AU - Mahajan, Rajiv
AU - Lau, Dennis
AU - Sanders, Prashanthan
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Objective To characterise the rate, causes and predictors of cessation of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF). Patients and methods Consecutive patients with AF with a long-term anticoagulation indication treated with NOACs (dabigatran, apixaban and rivaroxaban) in our centre from September 2010 through December 2016 were included. Prospectively collected data with baseline characteristics, causes of cessation, mean duration-to-cessation and predictors of cessation were analysed. Results The study comprised 1415 consecutive patients with AF, of whom 439 had a CHA 2 DS 2 -VASc≥1 and were on a NOAC. Mean age was 71.9±8.7 years and 37% were females. Over a median follow-up of 3.6 years (IQR=2.7-5.3), 147 (33.5%) patients ceased their index-NOAC (113 switched to a different form of OAC), at a rate of 8.8 per 100 patient-years. Serious adverse events warranting NOAC cessation occurred in 28 patients (6.4%) at a rate of 1.6 events per 100 patient-years. The mean duration-to-cessation was 4.9 years (95% CI 4.6 to 5.1) and apixaban had the longest duration-to-cessation with (5.1, 95% CI 4.8 to 5.4) years, compared with dabigatran (4.6, 95% CI 4.2 to 4.9) and rivaroxaban (4.5, 95% CI 3.9 to 5.1), pairwise log-rank p=0.002 and 0.025, respectively. In multivariable analyses, age was an independent predictor of index-NOAC cessation (HR 1.03, 95% CI 1.01 to 1.05; p=0.006). Female gender (HR 2.2, 95% CI 1.04 to 4.64; p=0.04) independently predicted serious adverse events. Conclusion In this a € real world' cohort, NOAC use is safe and well-tolerated when prescribed in an integrated care clinic. Whether apixaban is better tolerated compared with other NOACs warrants further study.
AB - Objective To characterise the rate, causes and predictors of cessation of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF). Patients and methods Consecutive patients with AF with a long-term anticoagulation indication treated with NOACs (dabigatran, apixaban and rivaroxaban) in our centre from September 2010 through December 2016 were included. Prospectively collected data with baseline characteristics, causes of cessation, mean duration-to-cessation and predictors of cessation were analysed. Results The study comprised 1415 consecutive patients with AF, of whom 439 had a CHA 2 DS 2 -VASc≥1 and were on a NOAC. Mean age was 71.9±8.7 years and 37% were females. Over a median follow-up of 3.6 years (IQR=2.7-5.3), 147 (33.5%) patients ceased their index-NOAC (113 switched to a different form of OAC), at a rate of 8.8 per 100 patient-years. Serious adverse events warranting NOAC cessation occurred in 28 patients (6.4%) at a rate of 1.6 events per 100 patient-years. The mean duration-to-cessation was 4.9 years (95% CI 4.6 to 5.1) and apixaban had the longest duration-to-cessation with (5.1, 95% CI 4.8 to 5.4) years, compared with dabigatran (4.6, 95% CI 4.2 to 4.9) and rivaroxaban (4.5, 95% CI 3.9 to 5.1), pairwise log-rank p=0.002 and 0.025, respectively. In multivariable analyses, age was an independent predictor of index-NOAC cessation (HR 1.03, 95% CI 1.01 to 1.05; p=0.006). Female gender (HR 2.2, 95% CI 1.04 to 4.64; p=0.04) independently predicted serious adverse events. Conclusion In this a € real world' cohort, NOAC use is safe and well-tolerated when prescribed in an integrated care clinic. Whether apixaban is better tolerated compared with other NOACs warrants further study.
KW - anticoagulants
KW - atrial fibrillation (AF)
KW - NOACs
KW - dabigatran
KW - apixaban
KW - rivaroxaban
KW - atrial fibrillation
KW - pharmacology
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85093957532&partnerID=8YFLogxK
U2 - 10.1136/heartjnl-2020-317418
DO - 10.1136/heartjnl-2020-317418
M3 - Article
C2 - 33067328
AN - SCOPUS:85093957532
SN - 1355-6037
VL - 107
SP - 971
EP - 976
JO - Heart
JF - Heart
IS - 12
M1 - 317418
ER -