CGRP immunoreactive neurons in rat dorsal root ganglia do not all contain low-affinity NGF receptor immunoreactivity

Xin Fu Zhou; Wei Ping Gai; Robert A. Rush

doi:10.1016/0006-8993(93)91679-M

CGRP immunoreactive neurons in rat dorsal root ganglia do not all contain low-affinity NGF receptor immunoreactivity

Xin Fu Zhou, Wei Ping Gai, Robert A. Rush

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Nerve growth factor (NGF) and its homologues bind to the low affinity NGF receptor (LNGFR). We have determined whether the LNGFR colocalizes with calcitonin gene-related peptide (CGRP) as this peptide is restricted to neurons exhibiting high affinity binding sites for NGF. LNGFR and CGRP immunoreactivities were detected in 57% and 49% of spinal ganglion neurons respectively with different soma areas and only partial colocalization. Our data suggest that the LNGFR may not be essential for a functional neurotrophin response.

Original language	English
Pages (from-to)	322-325
Number of pages	4
Journal	Brain Research
Volume	612
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(93)91679-M
Publication status	Published - 28 May 1993

Keywords

Calcitonin gene-related peptide
Dorsal root ganglion
Immunohistochemistry
Nerve growth factor receptor
Sensory neuron

Access to Document

10.1016/0006-8993(93)91679-MLicence: In Copyright

Cite this

@article{e1d42f7ed42347b4b712394657b9fd61,

title = "CGRP immunoreactive neurons in rat dorsal root ganglia do not all contain low-affinity NGF receptor immunoreactivity",

abstract = "Nerve growth factor (NGF) and its homologues bind to the low affinity NGF receptor (LNGFR). We have determined whether the LNGFR colocalizes with calcitonin gene-related peptide (CGRP) as this peptide is restricted to neurons exhibiting high affinity binding sites for NGF. LNGFR and CGRP immunoreactivities were detected in 57% and 49% of spinal ganglion neurons respectively with different soma areas and only partial colocalization. Our data suggest that the LNGFR may not be essential for a functional neurotrophin response.",

keywords = "Calcitonin gene-related peptide, Dorsal root ganglion, Immunohistochemistry, Nerve growth factor receptor, Sensory neuron",

author = "Zhou, {Xin Fu} and Gai, {Wei Ping} and Rush, {Robert A.}",

year = "1993",

month = may,

day = "28",

doi = "10.1016/0006-8993(93)91679-M",

language = "English",

volume = "612",

pages = "322--325",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - CGRP immunoreactive neurons in rat dorsal root ganglia do not all contain low-affinity NGF receptor immunoreactivity

AU - Zhou, Xin Fu

AU - Gai, Wei Ping

AU - Rush, Robert A.

PY - 1993/5/28

Y1 - 1993/5/28

N2 - Nerve growth factor (NGF) and its homologues bind to the low affinity NGF receptor (LNGFR). We have determined whether the LNGFR colocalizes with calcitonin gene-related peptide (CGRP) as this peptide is restricted to neurons exhibiting high affinity binding sites for NGF. LNGFR and CGRP immunoreactivities were detected in 57% and 49% of spinal ganglion neurons respectively with different soma areas and only partial colocalization. Our data suggest that the LNGFR may not be essential for a functional neurotrophin response.

AB - Nerve growth factor (NGF) and its homologues bind to the low affinity NGF receptor (LNGFR). We have determined whether the LNGFR colocalizes with calcitonin gene-related peptide (CGRP) as this peptide is restricted to neurons exhibiting high affinity binding sites for NGF. LNGFR and CGRP immunoreactivities were detected in 57% and 49% of spinal ganglion neurons respectively with different soma areas and only partial colocalization. Our data suggest that the LNGFR may not be essential for a functional neurotrophin response.

KW - Calcitonin gene-related peptide

KW - Dorsal root ganglion

KW - Immunohistochemistry

KW - Nerve growth factor receptor

KW - Sensory neuron

UR - http://www.scopus.com/inward/record.url?scp=0027286597&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(93)91679-M

DO - 10.1016/0006-8993(93)91679-M

M3 - Article

C2 - 8101135

AN - SCOPUS:0027286597

SN - 0006-8993

VL - 612

SP - 322

EP - 325

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

CGRP immunoreactive neurons in rat dorsal root ganglia do not all contain low-affinity NGF receptor immunoreactivity

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this