CGRP immunoreactive neurons in rat dorsal root ganglia do not all contain low-affinity NGF receptor immunoreactivity

Xin Fu Zhou, Wei Ping Gai, Robert A. Rush

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Nerve growth factor (NGF) and its homologues bind to the low affinity NGF receptor (LNGFR). We have determined whether the LNGFR colocalizes with calcitonin gene-related peptide (CGRP) as this peptide is restricted to neurons exhibiting high affinity binding sites for NGF. LNGFR and CGRP immunoreactivities were detected in 57% and 49% of spinal ganglion neurons respectively with different soma areas and only partial colocalization. Our data suggest that the LNGFR may not be essential for a functional neurotrophin response.

    Original languageEnglish
    Pages (from-to)322-325
    Number of pages4
    JournalBrain Research
    Volume612
    Issue number1-2
    DOIs
    Publication statusPublished - 28 May 1993

    Keywords

    • Calcitonin gene-related peptide
    • Dorsal root ganglion
    • Immunohistochemistry
    • Nerve growth factor receptor
    • Sensory neuron

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