CGRP immunoreactive neurons in rat dorsal root ganglia do not all contain low-affinity NGF receptor immunoreactivity

Xin Fu Zhou, Wei Ping Gai, Robert A. Rush

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Nerve growth factor (NGF) and its homologues bind to the low affinity NGF receptor (LNGFR). We have determined whether the LNGFR colocalizes with calcitonin gene-related peptide (CGRP) as this peptide is restricted to neurons exhibiting high affinity binding sites for NGF. LNGFR and CGRP immunoreactivities were detected in 57% and 49% of spinal ganglion neurons respectively with different soma areas and only partial colocalization. Our data suggest that the LNGFR may not be essential for a functional neurotrophin response.

    Original languageEnglish
    Pages (from-to)322-325
    Number of pages4
    JournalBrain Research
    Volume612
    Issue number1-2
    DOIs
    Publication statusPublished - 28 May 1993

    Keywords

    • Calcitonin gene-related peptide
    • Dorsal root ganglion
    • Immunohistochemistry
    • Nerve growth factor receptor
    • Sensory neuron

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