Abstract
Animal models of osteoarthritis (OA) are important tools to understand the pathology of OA. Moreover, knowledge of early pathological changes is essential for early treatment options and to develop better therapeutic agents to modify the disease progression. Although OA involves the whole joint, there is increasing evidence that
changes in the subchondral trabecular bone are also an underlying cause. The purpose of this study was to perform a comprehensive longitudinal in vivo characterisation of a rat model of low-dose monosodium iodoacetate (MIA)-induced OA that closely mimics progressive human OA, using noninvasive in vivo micro-CT imaging.
changes in the subchondral trabecular bone are also an underlying cause. The purpose of this study was to perform a comprehensive longitudinal in vivo characterisation of a rat model of low-dose monosodium iodoacetate (MIA)-induced OA that closely mimics progressive human OA, using noninvasive in vivo micro-CT imaging.
Original language | English |
---|---|
Pages (from-to) | S61-S62 |
Number of pages | 2 |
Journal | Osteoarthritis and Cartilage |
Volume | 19 |
Issue number | Supplement 1 |
DOIs | |
Publication status | Published - 2011 |
Externally published | Yes |
Event | World Congress on Osteoarthritis 2011 - San Diego, United States Duration: 15 Sept 2011 → 18 Sept 2011 |