Characterisation of temporal subchondral bone changes in a rat model of low-dose monosodium iodoacetate induced osteoarthritis: an in vivo micro-CT study

Geetha Mohan, Egon Perilli, Julia Kuliwaba, Ian Parkinson, Julia Humphries, Nick Fazzalari

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Animal models of osteoarthritis (OA) are important tools to understand the pathology of OA. Moreover, knowledge of early pathological changes is essential for early treatment options and to develop better therapeutic agents to modify the disease progression. Although OA involves the whole joint, there is increasing evidence that
changes in the subchondral trabecular bone are also an underlying cause. The purpose of this study was to perform a comprehensive longitudinal in vivo characterisation of a rat model of low-dose monosodium iodoacetate (MIA)-induced OA that closely mimics progressive human OA, using noninvasive in vivo micro-CT imaging.
Original languageEnglish
Pages (from-to)S61-S62
Number of pages2
JournalOsteoarthritis and Cartilage
Volume19
Issue numberSupplement 1
DOIs
Publication statusPublished - 2011
Externally publishedYes
EventWorld Congress on Osteoarthritis 2011 - San Diego, United States
Duration: 15 Sep 201118 Sep 2011

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