Characterization of chloroquine plasma protein binding in man.

O. Walker; DJ Birkett; G. Alvan; LL Gustafsson; F. Sjoqvist

doi:10.1111/j.1365-2125.1983.tb01513.x

Characterization of chloroquine plasma protein binding in man.

O. Walker
, DJ Birkett
, G. Alvan
, LL Gustafsson
, F. Sjoqvist

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Chloroquine protein binding was determined by equilibrium dialysis of purified plasma proteins and plasma samples from 20 healthy subjects and 14 patients with rheumatoid arthritis. The mean binding was 61 +/‐ 9% in plasma from healthy subjects (range 46‐74%) and 64 +/‐ 7% in plasma from rheumatoid arthritis patients (range 55‐79%). Albumin and alpha 1‐acid glycoprotein at physiological concentrations bound chloroquine to an approximately equal extent. Protein binding is unlikely to be an important determinant of chloroquine pharmacokinetics or response. 1983 The British Pharmacological Society

Original language	English
Pages (from-to)	375-377
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	15
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2125.1983.tb01513.x
Publication status	Published - Mar 1983

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10.1111/j.1365-2125.1983.tb01513.xLicence: In Copyright

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title = "Characterization of chloroquine plasma protein binding in man.",

abstract = "Chloroquine protein binding was determined by equilibrium dialysis of purified plasma proteins and plasma samples from 20 healthy subjects and 14 patients with rheumatoid arthritis. The mean binding was 61 +/‐ 9\% in plasma from healthy subjects (range 46‐74\%) and 64 +/‐ 7\% in plasma from rheumatoid arthritis patients (range 55‐79\%). Albumin and alpha 1‐acid glycoprotein at physiological concentrations bound chloroquine to an approximately equal extent. Protein binding is unlikely to be an important determinant of chloroquine pharmacokinetics or response. 1983 The British Pharmacological Society",

author = "O. Walker and DJ Birkett and G. Alvan and LL Gustafsson and F. Sjoqvist",

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AU - Walker, O.

AU - Birkett, DJ

AU - Alvan, G.

AU - Gustafsson, LL

AU - Sjoqvist, F.

PY - 1983/3

Y1 - 1983/3

N2 - Chloroquine protein binding was determined by equilibrium dialysis of purified plasma proteins and plasma samples from 20 healthy subjects and 14 patients with rheumatoid arthritis. The mean binding was 61 +/‐ 9% in plasma from healthy subjects (range 46‐74%) and 64 +/‐ 7% in plasma from rheumatoid arthritis patients (range 55‐79%). Albumin and alpha 1‐acid glycoprotein at physiological concentrations bound chloroquine to an approximately equal extent. Protein binding is unlikely to be an important determinant of chloroquine pharmacokinetics or response. 1983 The British Pharmacological Society

AB - Chloroquine protein binding was determined by equilibrium dialysis of purified plasma proteins and plasma samples from 20 healthy subjects and 14 patients with rheumatoid arthritis. The mean binding was 61 +/‐ 9% in plasma from healthy subjects (range 46‐74%) and 64 +/‐ 7% in plasma from rheumatoid arthritis patients (range 55‐79%). Albumin and alpha 1‐acid glycoprotein at physiological concentrations bound chloroquine to an approximately equal extent. Protein binding is unlikely to be an important determinant of chloroquine pharmacokinetics or response. 1983 The British Pharmacological Society

UR - https://www.scopus.com/pages/publications/0020693405

U2 - 10.1111/j.1365-2125.1983.tb01513.x

DO - 10.1111/j.1365-2125.1983.tb01513.x

M3 - Article

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AN - SCOPUS:0020693405

SN - 0306-5251

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SP - 375

EP - 377

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 3

ER -

Characterization of chloroquine plasma protein binding in man.

Abstract

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