Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells

Wenru Pan; Karlea Kremer; Xenia Kaidonis; Victoria Ludlow; Mary-Louise Rogers; Jianling Xie; Christopher Proud; Simon Koblar

doi:10.1016/j.ijdevneu.2016.07.007

Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells

Wenru Pan, Karlea Kremer, Xenia Kaidonis, Victoria Ludlow, Mary-Louise Rogers, Jianling Xie, Christopher Proud, Simon Koblar

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Human adult dental pulp stem cells (DPSC) are a heterogeneous stem cell population, which are able to differentiate down neural, chondrocyte, osteocyte and adipocyte lineages. We studied the expression pattern of p75 neurotrophin receptors (p75NTR), a marker of neural stem cells, within human DPSC populations from eight donors. p75NTR are expressed at low levels (<10%) in DPSC. Importantly, p75⁺ DPSC represent higher expression levels of SOX1 (neural precursor cell marker), SOX2 (cell pluripotency marker) and nestin (neural stem cell marker) in comparison to p75⁻ DPSC. Our results suggest that p75⁺ hDPSC may denote a subpopulation with greater neurogenic potential.

Original language	English
Pages (from-to)	90-98
Number of pages	9
Journal	International Journal of Developmental Neuroscience
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/j.ijdevneu.2016.07.007
Publication status	Published - 1 Oct 2016

Keywords

Dental pulp stem cells
Neural crest stem cells
p75 Neurotrophin receptor
SOX2
SOX9

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10.1016/j.ijdevneu.2016.07.007

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title = "Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells",

abstract = "Human adult dental pulp stem cells (DPSC) are a heterogeneous stem cell population, which are able to differentiate down neural, chondrocyte, osteocyte and adipocyte lineages. We studied the expression pattern of p75 neurotrophin receptors (p75NTR), a marker of neural stem cells, within human DPSC populations from eight donors. p75NTR are expressed at low levels (<10%) in DPSC. Importantly, p75+ DPSC represent higher expression levels of SOX1 (neural precursor cell marker), SOX2 (cell pluripotency marker) and nestin (neural stem cell marker) in comparison to p75− DPSC. Our results suggest that p75+ hDPSC may denote a subpopulation with greater neurogenic potential.",

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AU - Pan, Wenru

AU - Kremer, Karlea

AU - Kaidonis, Xenia

AU - Ludlow, Victoria

AU - Rogers, Mary-Louise

AU - Xie, Jianling

AU - Proud, Christopher

AU - Koblar, Simon

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Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells

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