Characterization of p75 neurotrophin receptor expression in human dental pulp stem cells

Wenru Pan, Karlea Kremer, Xenia Kaidonis, Victoria Ludlow, Mary-Louise Rogers, Jianling Xie, Christopher Proud, Simon Koblar

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Human adult dental pulp stem cells (DPSC) are a heterogeneous stem cell population, which are able to differentiate down neural, chondrocyte, osteocyte and adipocyte lineages. We studied the expression pattern of p75 neurotrophin receptors (p75NTR), a marker of neural stem cells, within human DPSC populations from eight donors. p75NTR are expressed at low levels (<10%) in DPSC. Importantly, p75+ DPSC represent higher expression levels of SOX1 (neural precursor cell marker), SOX2 (cell pluripotency marker) and nestin (neural stem cell marker) in comparison to p75 DPSC. Our results suggest that p75+ hDPSC may denote a subpopulation with greater neurogenic potential.

    Original languageEnglish
    Pages (from-to)90-98
    Number of pages9
    JournalInternational Journal of Developmental Neuroscience
    Volume53
    Issue number1
    DOIs
    Publication statusPublished - 1 Oct 2016

    Keywords

    • Dental pulp stem cells
    • Neural crest stem cells
    • p75 Neurotrophin receptor
    • SOX2
    • SOX9

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