Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system

Ian T. Paulsen; Melissa H. Brown; Ronald A. Skurray

Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system

Ian T. Paulsen, Melissa H. Brown, Ronald A. Skurray

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.

Original language	English
Pages (from-to)	3477-3479
Number of pages	3
Journal	Journal of Bacteriology
Volume	180
Issue number	13
Publication status	Published - Jul 1998
Externally published	Yes

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title = "Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system",

abstract = "The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.",

author = "Paulsen, {Ian T.} and Brown, {Melissa H.} and Skurray, {Ronald A.}",

year = "1998",

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AU - Paulsen, Ian T.

AU - Brown, Melissa H.

AU - Skurray, Ronald A.

PY - 1998/7

Y1 - 1998/7

N2 - The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.

AB - The staphylococcal qacB-encoding multidrug resistance plasmid pSK156, isolated from a clinical strain dating from 1951, was characterized. Comparison of the regions flanking qacB with other qacA- and qacB-encoding plasmids provided insights into the evolution and dissemination of these multidrug efflux genes and led to the detection of the earliest known copy of the insertion sequence IS257.

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M3 - Article

C2 - 9642206

AN - SCOPUS:0031749891

SN - 0021-9193

VL - 180

SP - 3477

EP - 3479

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 13

ER -

Characterization of the earliest known Staphylococcus aureus plasmid encoding a multidrug efflux system

Abstract

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