Chemical coding of neurons in the gastrointestinal tract

M. Costa, S. Brookes, P. Steele, J. Vickers

    Research output: Chapter in Book/Report/Conference proceedingChapter

    13 Citations (Scopus)

    Abstract

    The gastrointestinal tract, unlike most of the other internal organs, contains a rich and complex neuronal system embedded within its wall. The first description of this system dates back to the middle of the last century when Meissner and Auerbach first described the rich neuronal network made of microganglia and nerve bundles forming the myenteric and submucous plexuses (Meissner, 1857; Auerbach, 1864). By the turn of the century Bayliss and Starling (1889) first, followed by Langley (1921), provided evidence that this system, named then the Enteric Nervous System (ENS) controls coordinated motor functions in isolation from the central nervous system. In addition the intestine receives inputs from the central nervous system via sympathetic and parasympathetic nerves and sends sensory information via vagal and spinal afferent neurons. Between the beginning of this century and around twenty years ago the attempts to identify neuroanatomically the different classes of enteric neurons involved in the control of intestinal functions were hampered by the inability of the neurohistological techniques to distinguish specific neuronal groups within the apparently homogeneous maze of nerve cells and nerve fibres which form the ENS.
    Original languageEnglish
    Title of host publicationSensory Nerves and Neuropeptides in Gastroenterology.
    Subtitle of host publicationFrom Basic Science to Clinical Perspectives
    EditorsM. Costa, C. Surrenti, S. Gorini, C.A. Maggi, A. Meli
    PublisherSpringer
    Pages17-27
    Number of pages11
    Volume298
    ISBN (Electronic)978-1-4899-0744-8
    ISBN (Print)978-1-4899-0746-2
    DOIs
    Publication statusPublished - 1991

    Publication series

    NameAdvances in Experimental Medicine and Biology
    PublisherKLUWER ACADEMIC/PLENUM PUBLISHERS
    ISSN (Print)0065-275X

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