Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 - potent 1d-1,4,5-InsP3-like calcium mobilizing analogues

Alan P. Kozikowski, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Syntheses of optically pure 1d-3-F-2,4,5-InsP3, 1d-3-F-1,2,4,5-InsP4, and 1d-1,2,4,5-InsP4 are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP3 in both binding and calcium release experiments.

Original languageEnglish
Pages (from-to)1295-1300
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number12
DOIs
Publication statusPublished - 22 Jun 1995
Externally publishedYes

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