Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 - potent 1d-1,4,5-InsP3-like calcium mobilizing analogues

Alan P. Kozikowski; Abdul H. Fauq; Robert A. Wilcox; Stefan R. Nahorski

doi:10.1016/0960-894X(95)00210-K

Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP₄ and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP₄ - potent 1d-1,4,5-InsP₃-like calcium mobilizing analogues

Alan P. Kozikowski, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Syntheses of optically pure 1d-3-F-2,4,5-InsP₃, 1d-3-F-1,2,4,5-InsP₄, and 1d-1,2,4,5-InsP₄ are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP₃ in both binding and calcium release experiments.

Original language	English
Pages (from-to)	1295-1300
Number of pages	6
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	5
Issue number	12
DOIs	https://doi.org/10.1016/0960-894X(95)00210-K
Publication status	Published - 22 Jun 1995
Externally published	Yes

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@article{c0825ace29864e5c9ef93cb2761294c7,

title = "Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 - potent 1d-1,4,5-InsP3-like calcium mobilizing analogues",

abstract = "Syntheses of optically pure 1d-3-F-2,4,5-InsP3, 1d-3-F-1,2,4,5-InsP4, and 1d-1,2,4,5-InsP4 are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP3 in both binding and calcium release experiments.",

author = "Kozikowski, {Alan P.} and Fauq, {Abdul H.} and Wilcox, {Robert A.} and Nahorski, {Stefan R.}",

year = "1995",

month = jun,

day = "22",

doi = "10.1016/0960-894X(95)00210-K",

language = "English",

volume = "5",

pages = "1295--1300",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "12",

}

Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP₄ and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP₄ - potent 1d-1,4,5-InsP₃-like calcium mobilizing analogues. / Kozikowski, Alan P.; Fauq, Abdul H.; Wilcox, Robert A. et al.
In: Bioorganic & Medicinal Chemistry Letters, Vol. 5, No. 12, 22.06.1995, p. 1295-1300.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 - potent 1d-1,4,5-InsP3-like calcium mobilizing analogues

AU - Kozikowski, Alan P.

AU - Fauq, Abdul H.

AU - Wilcox, Robert A.

AU - Nahorski, Stefan R.

PY - 1995/6/22

Y1 - 1995/6/22

N2 - Syntheses of optically pure 1d-3-F-2,4,5-InsP3, 1d-3-F-1,2,4,5-InsP4, and 1d-1,2,4,5-InsP4 are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP3 in both binding and calcium release experiments.

AB - Syntheses of optically pure 1d-3-F-2,4,5-InsP3, 1d-3-F-1,2,4,5-InsP4, and 1d-1,2,4,5-InsP4 are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP3 in both binding and calcium release experiments.

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U2 - 10.1016/0960-894X(95)00210-K

DO - 10.1016/0960-894X(95)00210-K

M3 - Article

AN - SCOPUS:0029076591

SN - 0960-894X

VL - 5

SP - 1295

EP - 1300

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 12

ER -

Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP₄ and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP₄ - potent 1d-1,4,5-InsP₃-like calcium mobilizing analogues

Abstract

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