TY - JOUR
T1 - Chemotherapy-induced mucositis
T2 - The role of mucin secretion and regulation, and the enteric nervous system
AU - Thorpe, Daniel
AU - Stringer, Andrea
AU - Butler, Ross
PY - 2013/9
Y1 - 2013/9
N2 - Alimentary mucositis is a severe, dose-limiting, toxic side effect of cytotoxic chemotherapy and radiotherapy. Patients with mucositis often have reductions or breaks imposed on cytotoxic therapy, which may lead to reduced survival. Furthermore, there is an increased risk of infection and hospitalization, compounding the cost of treatment. There are currently limited therapeutic options for mucositis, and no effective prevention available. Mucin expression and secretion have been shown to be associated with mucositis. Furthermore, mucins exhibit protective effects on the alimentary tract through reducing mechanical and chemical stress, preventing bacterial overgrowth and penetration, and digestion of the mucosa. Additionally, a number of studies have implicated some key neurotransmitters in both mucositis and mucin secretion, suggesting that the enteric nervous system may also play a key role in the development of mucositis.
AB - Alimentary mucositis is a severe, dose-limiting, toxic side effect of cytotoxic chemotherapy and radiotherapy. Patients with mucositis often have reductions or breaks imposed on cytotoxic therapy, which may lead to reduced survival. Furthermore, there is an increased risk of infection and hospitalization, compounding the cost of treatment. There are currently limited therapeutic options for mucositis, and no effective prevention available. Mucin expression and secretion have been shown to be associated with mucositis. Furthermore, mucins exhibit protective effects on the alimentary tract through reducing mechanical and chemical stress, preventing bacterial overgrowth and penetration, and digestion of the mucosa. Additionally, a number of studies have implicated some key neurotransmitters in both mucositis and mucin secretion, suggesting that the enteric nervous system may also play a key role in the development of mucositis.
KW - Alimentary mucositis
KW - Chemotherapy
KW - Enteric nervous system
KW - Mucins
UR - http://www.scopus.com/inward/record.url?scp=84881263451&partnerID=8YFLogxK
U2 - 10.1016/j.neuro.2013.06.007
DO - 10.1016/j.neuro.2013.06.007
M3 - Review article
C2 - 23827812
AN - SCOPUS:84881263451
SN - 0161-813X
VL - 38
SP - 101
EP - 105
JO - NEUROTOXICOLOGY
JF - NEUROTOXICOLOGY
ER -