Childhood respiratory risk factor profiles and middle-age lung function: A prospective cohort study from the first to sixth decade

Dinh S. Bui, Haydn E. Walters, John A. Burgess, Jennifer L. Perret, Minh Q. Bui, Gayan Bowatte, Adrian J. Lowe, Melissa A. Russell, Bruce R. Thompson, Garun S. Hamilton, Alan L. James, Graham G. Giles, Paul S. Thomas, Debbie Jarvis, Cecilie Svanes, Judith Garcia-Aymerich, Bircan Erbas, Peter A. Frith, Katrina J. Allen, Michael J. AbramsonCaroline J. Lodge, Shyamali C. Dharmage

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)


    Rationale: Childhood risk factors for long-term lung health often coexist and their specific patterns may affect subsequent lung function differently. Objectives: To identify childhood risk factor profiles and their influence on lung function and chronic obstructive pulmonary disease (COPD) in middle age, and potential pathways. Methods: Profiles of 11 childhood respiratory risk factors, documented at age 7, were identified in 8,352 participants from the Tasmanian Longitudinal Health Study using latent class analysis. We investigated associations between risk profiles and post-bronchodilator lung function and COPD at age 53, mediation by childhood lung function and adult asthma, and interaction with personal smoking. Results: Six risk profiles were identified: 1) unexposed or least exposed (49%); 2) parental smoking (21.5%); 3) allergy (10%); 4) frequent asthma, bronchitis (8.7%); 5) infrequent asthma, bronchitis (8.3%); and 6) frequent asthma, bronchitis, allergy (2.6%). Profile 6 was most strongly associated with lower forced expiratory volume in 1 second (FEV1) (2261; 95% confidence interval, 2373 to 2148 ml); lower FEV1/forced vital capacity (FVC) (23.4; 24.8 to 21.9%) and increased COPD risk (odds ratio, 4.9; 2.1 to 11.0) at age 53. The effect of profile 6 on COPD was largely mediated by adult active asthma (62.5%) and reduced childhood lung function (26.5%). Profiles 2 and 4 had smaller adverse effects than profile 6. Notably, the effects of profiles 2 and 6 were synergistically stronger for smokers. Conclusions: Profiles of childhood respiratory risk factors predict middle-age lung function levels and COPD risk. Specifically, children with frequent asthma attacks and allergies, especially if they also become adult smokers, are the most vulnerable group. Targeting active asthma in adulthood (i.e., a dominant mediator) and smoking (i.e., an effect modifier) may block causal pathways and lessen the effect of such established early-life exposures.

    Original languageEnglish
    Pages (from-to)1057-1066
    Number of pages10
    JournalAnnals of the American Thoracic Society
    Issue number9
    Publication statusPublished - Sept 2018


    • Childhood
    • Chronic obstructive pulmonary disease
    • Lung function
    • Profiles
    • Risk factors


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