Chiral discrimination of basic and hydrophobic molecules by chemical force spectroscopy

Mrinal Mahapatro, Christopher Gibson, Chris Abell, Trevor Rayment

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Chemical force spectroscopy (CFS) is becoming a powerful technique with which to measure intermolecular forces. The prime advantage over other techniques is the ability to map spatial distribution of ligands on the surface. We have used CFS to explore the binding force of a variety of different chiral molecules in order to understand more about the nature of what is a fundamental aspect of chemical biology and of central importance in pharmacology.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalUltramicroscopy
Volume97
Issue number1-4
DOIs
Publication statusPublished - Oct 2003
Externally publishedYes

Keywords

  • Chemical force spectroscopy
  • Chiral discrimination

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