Choline acetyltransferase- and peptide immunoreactivity of submucous neurons in the small intestine of the guinea-pig

J. B. Furness, M. Costa, J. R. Keast

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    216 Citations (Scopus)

    Abstract

    The peptides cholecystokinin (CCK), neuropeptide Y (NPY), somatostatin (SOM), substance P (SP) and vasoactive intestinal peptide (VIP), and the synthesizing enzyme for acetylcholine, choline acetyltransferase (ChAT) were localized immunohistochemically in nerve cell bodies of the submucous ganglia in the small intestine of the guinea-pig. VIP-like immunoreactivity was found in 45% of submucous neurons. ChAT immunoreactivity was observed in a separate group of nerve cells, which made up 54% of the total population. There were three subsets of neurons immunoreactive for ChAT: (1) ChAT neurons that also contained immunoreactivity for each of the peptides CCK, SOM and NPY, representing 29% of all submucous neurons; (2) ChAT neurons that also contained SP-like immunoreactivity, representing 11% of all submucous neurons, and (3) ChAT cells that did not contain any detectable amount of the peptides that were localized in this study.

    Original languageEnglish
    Pages (from-to)329-336
    Number of pages8
    JournalCell and Tissue Research
    Volume237
    Issue number2
    DOIs
    Publication statusPublished - Aug 1984

    Keywords

    • Cholecystokinin
    • Choline acetyltransferase
    • Guinea-pig
    • Intestine, small
    • Neuropeptide Y
    • Somatostatin
    • Submucous ganglia
    • Substance P

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