Chromatin Structure: A Property of the Higher Structure of Chromatin and the Time Course of Its Formation During Chromatin Replication

L. A. Burgoyne; J. D. Mobbs; A. J. Marshall

doi:10.1093/nar/3.12.3293

Chromatin Structure: A Property of the Higher Structure of Chromatin and the Time Course of Its Formation During Chromatin Replication

L. A. Burgoyne
, J. D. Mobbs
, A. J. Marshall

College of Science and Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The action of a number of enzymes and metals on one nuclear preparation were interpreted in terms of the existence of a fragile but highly DNAase-I resistant feature of chromatin superstructure. The generation of this DNAase-I resistance feature of chromatin was then followed during normal DNA synthesis in the regenerating rat liver by following the disappearance of a transitory DNAase-I susceptible state. This transitory, DNAase-I susceptible state appears to be extremely similar to the post-synthetic, DNAase-I susceptible state that has been described in HeLa³².

Original language	English
Pages (from-to)	3293-3304
Number of pages	12
Journal	Nucleic Acids Research
Volume	3
Issue number	12
DOIs	https://doi.org/10.1093/nar/3.12.3293
Publication status	Published - 1 Dec 1976

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AB - The action of a number of enzymes and metals on one nuclear preparation were interpreted in terms of the existence of a fragile but highly DNAase-I resistant feature of chromatin superstructure. The generation of this DNAase-I resistance feature of chromatin was then followed during normal DNA synthesis in the regenerating rat liver by following the disappearance of a transitory DNAase-I susceptible state. This transitory, DNAase-I susceptible state appears to be extremely similar to the post-synthetic, DNAase-I susceptible state that has been described in HeLa32.

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Chromatin Structure: A Property of the Higher Structure of Chromatin and the Time Course of Its Formation During Chromatin Replication

Abstract

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