Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll

Dawei Liu, Zeeshan Shaukat, Robert Saint, Stephen Gregory

Research output: Contribution to journalArticle

10 Citations (Scopus)
1 Downloads (Pure)

Abstract

Chromosomal instability (CIN) is a hallmark of cancer and has been implicated in cancer initiation, progression and the development of resistance to traditional cancer therapy. Here we identify a new property of CIN cells, showing that inducing CIN in proliferating Drosophila larval tissue leads to the activation of innate immune signalling in CIN cells. Manipulation of this immune pathway strongly affects the survival of CIN cells, primarily via JNK, which responds to both Toll and TNFα/Eiger. This pathway also activates Mmp1, which recruits hemocytes to the CIN tissue to provide local amplification of the immune response that is needed for effective elimination of CIN cells.

Original languageEnglish
Pages (from-to)38552-38565
Number of pages14
JournalOncotarget
Volume6
Issue number36
DOIs
Publication statusPublished - 8 Oct 2015

Bibliographical note

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Keywords

  • chromosomal instability
  • innate immune response
  • Drosophila
  • TNFα
  • TLRs
  • Immunology Section
  • immunity
  • immune response

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