Chronic Lymphocytic Leukaemia Relies on Lipid Scavenging and Synthesis as an Energy Source

Lauren Thurgood; Lara Escane; Christie Bader; Karen Lower; Doug Brooks; Bryone Kuss

doi:10.1016/j.exphem.2019.06.446

Chronic Lymphocytic Leukaemia Relies on Lipid Scavenging and Synthesis as an Energy Source

Lauren Thurgood, Lara Escane, Christie Bader, Karen Lower, Doug Brooks, Bryone Kuss

College of Medicine and Public Health

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Dysregulation of cancer cell bioenergetics is one of the hallmarks of cancer. The Warburg effect is one such documented change. However, glucose metabolism is not universally increased in cancer cells. Uptake of 18F-FDG in chronic lymphocytic leukemia (CLL) fails as a marker of proliferation and whilst the underlying reason is poorly understood it suggests that CLL cells utilize energy sources other than glucose to proliferate. Using genetic, proteomic and lipidomic analyses, complemented with microscopy and nutrient uptake assays the preferred metabolic pathways of CLL cells have been identified.

Original language	English
Pages (from-to)	S89
Number of pages	1
Journal	Experimental Hematology
Volume	76
Issue number	Supplement
DOIs	https://doi.org/10.1016/j.exphem.2019.06.446
Publication status	Published - Aug 2019
Event	48th ISEH Annual Scientific Meeting - Brisbane Convention & Exhibition Centre, Brisbane, Australia Duration: 22 Aug 2019 → 25 Aug 2019

Keywords

Chronic lymphocytic leukaemia
Warburg effect
lipid scavenging
18F-FDG
energy sources
Lipid synthesis

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title = "Chronic Lymphocytic Leukaemia Relies on Lipid Scavenging and Synthesis as an Energy Source",

abstract = "Dysregulation of cancer cell bioenergetics is one of the hallmarks of cancer. The Warburg effect is one such documented change. However, glucose metabolism is not universally increased in cancer cells. Uptake of 18F-FDG in chronic lymphocytic leukemia (CLL) fails as a marker of proliferation and whilst the underlying reason is poorly understood it suggests that CLL cells utilize energy sources other than glucose to proliferate. Using genetic, proteomic and lipidomic analyses, complemented with microscopy and nutrient uptake assays the preferred metabolic pathways of CLL cells have been identified.",

keywords = "Chronic lymphocytic leukaemia, Warburg effect, lipid scavenging, 18F-FDG, energy sources, Lipid synthesis",

author = "Lauren Thurgood and Lara Escane and Christie Bader and Karen Lower and Doug Brooks and Bryone Kuss",

year = "2019",

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doi = "10.1016/j.exphem.2019.06.446",

language = "English",

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journal = "Experimental Hematology",

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TY - JOUR

T1 - Chronic Lymphocytic Leukaemia Relies on Lipid Scavenging and Synthesis as an Energy Source

AU - Thurgood, Lauren

AU - Escane, Lara

AU - Bader, Christie

AU - Lower, Karen

AU - Brooks, Doug

AU - Kuss, Bryone

PY - 2019/8

Y1 - 2019/8

N2 - Dysregulation of cancer cell bioenergetics is one of the hallmarks of cancer. The Warburg effect is one such documented change. However, glucose metabolism is not universally increased in cancer cells. Uptake of 18F-FDG in chronic lymphocytic leukemia (CLL) fails as a marker of proliferation and whilst the underlying reason is poorly understood it suggests that CLL cells utilize energy sources other than glucose to proliferate. Using genetic, proteomic and lipidomic analyses, complemented with microscopy and nutrient uptake assays the preferred metabolic pathways of CLL cells have been identified.

AB - Dysregulation of cancer cell bioenergetics is one of the hallmarks of cancer. The Warburg effect is one such documented change. However, glucose metabolism is not universally increased in cancer cells. Uptake of 18F-FDG in chronic lymphocytic leukemia (CLL) fails as a marker of proliferation and whilst the underlying reason is poorly understood it suggests that CLL cells utilize energy sources other than glucose to proliferate. Using genetic, proteomic and lipidomic analyses, complemented with microscopy and nutrient uptake assays the preferred metabolic pathways of CLL cells have been identified.

KW - Chronic lymphocytic leukaemia

KW - Warburg effect

KW - lipid scavenging

KW - 18F-FDG

KW - energy sources

KW - Lipid synthesis

U2 - 10.1016/j.exphem.2019.06.446

DO - 10.1016/j.exphem.2019.06.446

M3 - Meeting Abstract

SN - 0301-472X

VL - 76

SP - S89

JO - Experimental Hematology

JF - Experimental Hematology

IS - Supplement

T2 - 48th ISEH Annual Scientific Meeting

Y2 - 22 August 2019 through 25 August 2019

ER -

Chronic Lymphocytic Leukaemia Relies on Lipid Scavenging and Synthesis as an Energy Source

Abstract

Keywords

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