TY - JOUR
T1 - Chronic vasopressin antagonism in two-kidney, one-clip renovascular hypertension
AU - Burrell, L. M.
AU - Risvanis, J.
AU - Phillips, P. A.
AU - Naitoh, M.
AU - Johnston, C. I.
PY - 1997
Y1 - 1997
N2 - The role of vasopressin (AVP) in the maintenance of hypertension in the rat model of two-kidney, one-clip (2K1C) Goldblatt hypertension was assessed using the nonpeptide orally effective V1a receptor antagonist, OPC-21268. Rats were studied eight weeks after surgery when mean arterial pressure (MAP) was significantly increased in 2K1C rats compared to SHAM operated controls (2K1C 139±6, SHAM 106±3, P<0.01). Neither acute (OPC-21268, 30mg/kg) nor chronic (OPC-21268, 30mg/kg twice daily) V1a receptor blockade reduced blood pressure in either 2K1C or SHAM rats. The results of binding kinetic studies confirmed that OPC-21268 was effective at its putative site of action, the V1a receptor in both 2K1C and SHAM rats. These results indicate AVP is not involved in the maintenance of blood pressure in the 2K1C model of renovascular hypertension.
AB - The role of vasopressin (AVP) in the maintenance of hypertension in the rat model of two-kidney, one-clip (2K1C) Goldblatt hypertension was assessed using the nonpeptide orally effective V1a receptor antagonist, OPC-21268. Rats were studied eight weeks after surgery when mean arterial pressure (MAP) was significantly increased in 2K1C rats compared to SHAM operated controls (2K1C 139±6, SHAM 106±3, P<0.01). Neither acute (OPC-21268, 30mg/kg) nor chronic (OPC-21268, 30mg/kg twice daily) V1a receptor blockade reduced blood pressure in either 2K1C or SHAM rats. The results of binding kinetic studies confirmed that OPC-21268 was effective at its putative site of action, the V1a receptor in both 2K1C and SHAM rats. These results indicate AVP is not involved in the maintenance of blood pressure in the 2K1C model of renovascular hypertension.
KW - OPC-21268
KW - Renovascular hypertension
KW - Two-kidney, one-clip
KW - Vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0030860624&partnerID=8YFLogxK
U2 - 10.3109/10641969709083200
DO - 10.3109/10641969709083200
M3 - Article
C2 - 9247769
AN - SCOPUS:0030860624
VL - 19
SP - 981
EP - 991
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
SN - 1064-1963
IS - 5-6
ER -