Circulating cell-specific extracellular vesicles as biomarkers for the diagnosis and monitoring of chronic liver diseases

Lauren A. Newman, Kate Muller, Andrew Rowland

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic liver diseases represent a burgeoning health problem affecting billions of people worldwide. The insufficient performance of current minimally invasive tools is recognised as a significant barrier to the clinical management of these conditions. Extracellular vesicles (EVs) have emerged as a rich source of circulating biomarkers closely linked to pathological processes in originating tissues. Here, we summarise the contribution of EVs to normal liver function and to chronic liver pathologies; and explore the use of circulating EV biomarkers, with a particular focus on techniques to isolate and analyse cell- or tissue-specific EVs. Such approaches present a novel strategy to inform disease status and monitor changes in response to treatment in a minimally invasive manner. Emerging technologies that support the selective isolation and analysis of circulating EVs derived only from hepatic cells, have driven recent advancements in EV-based biomarker platforms for chronic liver diseases and show promise to bring these techniques to clinical settings.

Original languageEnglish
Article number232
Number of pages23
JournalCellular and Molecular Life Sciences
Volume79
Issue number5
DOIs
Publication statusPublished - May 2022

Keywords

  • Chronic liver disease
  • Extracellular vesicles
  • Metabolic-associated fatty liver disease
  • Minimally invasive biomarkers
  • Non-alcoholic fatty liver disease
  • Tissue-specific biomarkers

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