Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis

Panagiotis Paliogiannis; Alessandro G. Fois; Salvatore Sotgia; Arduino A. Mangoni; Elisabetta Zinellu; Pietro Pirina; Ciriaco Carru; Angelo Zinellu

doi:10.2217/bmm-2017-0420

Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis

Panagiotis Paliogiannis, Alessandro G. Fois, Salvatore Sotgia, Arduino A. Mangoni, Elisabetta Zinellu, Pietro Pirina, Ciriaco Carru, Angelo Zinellu

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean differences = 2.39 μmol/l, 95% CI: 1.50-3.28 μmol/l; p < 0.001). Our meta-analysis showed that the blood concentrations of MDA are consistently higher in patients with COPD when compared with healthy controls, suggesting an important role of lipid peroxidation, and thus oxidative stress, in the pathogenesis of COPD.

Original language	English
Pages (from-to)	771-781
Number of pages	11
Journal	Biomarkers in Medicine
Volume	12
Issue number	7
DOIs	https://doi.org/10.2217/bmm-2017-0420
Publication status	Published - Jul 2018

Keywords

ATS
chronic obstructive pulmonary disease
GOLD
lipid peroxidation
malondialdehyde
oxidative stress
plasma
serum
SMD
TBARS

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title = "Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis",

abstract = "The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean differences = 2.39 μmol/l, 95% CI: 1.50-3.28 μmol/l; p < 0.001). Our meta-analysis showed that the blood concentrations of MDA are consistently higher in patients with COPD when compared with healthy controls, suggesting an important role of lipid peroxidation, and thus oxidative stress, in the pathogenesis of COPD.",

keywords = "ATS, chronic obstructive pulmonary disease, GOLD, lipid peroxidation, malondialdehyde, oxidative stress, plasma, serum, SMD, TBARS",

author = "Panagiotis Paliogiannis and Fois, {Alessandro G.} and Salvatore Sotgia and Mangoni, {Arduino A.} and Elisabetta Zinellu and Pietro Pirina and Ciriaco Carru and Angelo Zinellu",

year = "2018",

month = jul,

doi = "10.2217/bmm-2017-0420",

language = "English",

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T2 - A systematic review and meta-analysis

AU - Paliogiannis, Panagiotis

AU - Fois, Alessandro G.

AU - Sotgia, Salvatore

AU - Mangoni, Arduino A.

AU - Zinellu, Elisabetta

AU - Pirina, Pietro

AU - Carru, Ciriaco

AU - Zinellu, Angelo

PY - 2018/7

Y1 - 2018/7

N2 - The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean differences = 2.39 μmol/l, 95% CI: 1.50-3.28 μmol/l; p < 0.001). Our meta-analysis showed that the blood concentrations of MDA are consistently higher in patients with COPD when compared with healthy controls, suggesting an important role of lipid peroxidation, and thus oxidative stress, in the pathogenesis of COPD.

AB - The aim of this meta-analysis was to review the available evidence regarding the blood concentrations of the oxidative stress marker malondialdehyde (MDA) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. 14 studies were included in the meta-analysis (from inception to October 2017) with a total of 817 COPD patients and 530 healthy controls. Pooled MDA concentrations were significantly higher in patients with COPD than controls (standardized mean differences = 2.39 μmol/l, 95% CI: 1.50-3.28 μmol/l; p < 0.001). Our meta-analysis showed that the blood concentrations of MDA are consistently higher in patients with COPD when compared with healthy controls, suggesting an important role of lipid peroxidation, and thus oxidative stress, in the pathogenesis of COPD.

KW - ATS

KW - chronic obstructive pulmonary disease

KW - GOLD

KW - lipid peroxidation

KW - malondialdehyde

KW - oxidative stress

KW - plasma

KW - serum

KW - SMD

KW - TBARS

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U2 - 10.2217/bmm-2017-0420

DO - 10.2217/bmm-2017-0420

M3 - Review article

C2 - 29865860

SN - 1752-0363

VL - 12

SP - 771

EP - 781

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 7

ER -

Circulating malondialdehyde concentrations in patients with stable chronic obstructive pulmonary disease: A systematic review and meta-analysis

Abstract

Keywords

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