Circulating microRNAs: emerging biomarkers for diagnosis and prognosis in patients with gastrointestinal cancers.

Kirsten Lindner, Joerg Haier, Zhe Wang, David Watson, Damian Hussey, Richard Hummel

    Research output: Contribution to journalReview articlepeer-review

    40 Citations (Scopus)

    Abstract

    To identify novel non-invasive biomarkers for improved detection, risk assessment and prognostic evaluation of cancer, expression profiles of circulating microRNAs are currently under evaluation. Circulating microRNAs are highly promising candidates in this context, as they present some key characteristics for cancer biomarkers: they are tissue-specific with reproducible expression and consistency among individuals from the same species, they are potentially derived directly from the tumour and therefore might correlate with tumour progression and recurrence, and they are bound to proteins or contained in subcellular particles, such as microvesicles or exosomes, making them highly stable and resistant to degradation. The present review highlights the origin of circulating microRNAs, their stability in blood samples, and techniques to isolate exosomal microRNAs, and then addresses the current evidence supporting potential clinical applications of circulating miRNAs for diagnostic and prognostic purposes.

    Original languageEnglish
    Pages (from-to)1-15
    Number of pages15
    JournalClinical Science
    Volume128
    Issue number1
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Cancer diagnosis
    • Cancer prognosis
    • Circulating exosomal microRNA
    • Circulating microRNA
    • Stability

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