Circulatory disturbances in multiple systems organ failure

Andrew Bersten, William J. Sibbald

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)


Circulatory disturbances in MSOF disturb normal metabolic autoregulation, the ability to continuously couple tissue oxygen delivery with oxygen need. These may occur at three levels of the circulation: the heart; the regional circulations; and the microcirculation. This article will summarize evidence demonstrating that MSOF is associated with reduced tissue oxygen delivery by virtue of changes in all three circulatory components governing the inadequacy of metabolic autoregulation in sepsis.

Original languageEnglish
Pages (from-to)233-254
Number of pages22
JournalCritical Care Clinics
Issue number2
Publication statusPublished - Apr 1989
Externally publishedYes


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