Circulatory disturbances in multiple systems organ failure

Andrew Bersten; William  J. Sibbald

doi:10.1016/s0749-0704(18)30434-2

Circulatory disturbances in multiple systems organ failure

Andrew Bersten, William J. Sibbald

Research output: Contribution to journal › Review article › peer-review

33 Citations (Scopus)

Abstract

Circulatory disturbances in MSOF disturb normal metabolic autoregulation, the ability to continuously couple tissue oxygen delivery with oxygen need. These may occur at three levels of the circulation: the heart; the regional circulations; and the microcirculation. This article will summarize evidence demonstrating that MSOF is associated with reduced tissue oxygen delivery by virtue of changes in all three circulatory components governing the inadequacy of metabolic autoregulation in sepsis.

Original language	English
Pages (from-to)	233-254
Number of pages	22
Journal	Critical Care Clinics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1016/s0749-0704(18)30434-2
Publication status	Published - Apr 1989
Externally published	Yes

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title = "Circulatory disturbances in multiple systems organ failure",

abstract = "Circulatory disturbances in MSOF disturb normal metabolic autoregulation, the ability to continuously couple tissue oxygen delivery with oxygen need. These may occur at three levels of the circulation: the heart; the regional circulations; and the microcirculation. This article will summarize evidence demonstrating that MSOF is associated with reduced tissue oxygen delivery by virtue of changes in all three circulatory components governing the inadequacy of metabolic autoregulation in sepsis.",

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AU - Bersten, Andrew

AU - Sibbald, William J.

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N2 - Circulatory disturbances in MSOF disturb normal metabolic autoregulation, the ability to continuously couple tissue oxygen delivery with oxygen need. These may occur at three levels of the circulation: the heart; the regional circulations; and the microcirculation. This article will summarize evidence demonstrating that MSOF is associated with reduced tissue oxygen delivery by virtue of changes in all three circulatory components governing the inadequacy of metabolic autoregulation in sepsis.

AB - Circulatory disturbances in MSOF disturb normal metabolic autoregulation, the ability to continuously couple tissue oxygen delivery with oxygen need. These may occur at three levels of the circulation: the heart; the regional circulations; and the microcirculation. This article will summarize evidence demonstrating that MSOF is associated with reduced tissue oxygen delivery by virtue of changes in all three circulatory components governing the inadequacy of metabolic autoregulation in sepsis.

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DO - 10.1016/s0749-0704(18)30434-2

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JO - Critical Care Clinics

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Circulatory disturbances in multiple systems organ failure

Abstract

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