Classification of normal and abnormal colonic motility based on cross-correlations of pancolonic manometry data

Lukasz Wiklendt, Sahar Mohammed, S Scott, Philip Dinning

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Background Manual analysis of data acquired from manometric studies of colonic motility is laborious, subject to laboratory bias and not specific enough to differentiate all patients from control subjects. Utilizing a cross-correlation technique, we have developed an automated analysis technique that can reliably differentiate the motor patterns of patients with slow transit constipation (STC) from those recorded in healthy controls. Methods Pancolonic manometric data were recorded from 17 patients with STC and 14 healthy controls. The automated analysis involved calculation of an indicator value derived from cross-correlations calculated between adjacent recording sites in a manometric trace. The automated technique was conducted on blinded real data sets (observed) and then to determine the likelihood of positive indicator values occurring by chance, the channel number within each individual data set were randomized (expected) and reanalyzed. Key Results In controls, the observed indicator value (3.2±1.4) was significantly greater than that predicted by chance (0.8±1.5; P<0.0001). In patients, the observed indicator value (-2.7±1.8) did not differ from that predicted by chance (-3.5±1.6; P=0.1). The indicator value for controls differed significantly from that of patients (P<0.0001), with all individual patients falling outside of the range of indicator values for controls. Conclusions & Inferences Automated analysis of colonic manometry data using cross-correlation separated all patients from controls. This automated technique indicates that the contractile motor patterns in STC patients differ from those recorded in healthy controls. The analytical technique may represent a means for defining subtypes of constipation.

    Original languageEnglish
    Pages (from-to)e215-e223
    Number of pages9
    JournalNeurogastroenterology and Motility
    Issue number3
    Publication statusPublished - Mar 2013


    • Automated analysis
    • Colon
    • Manometry


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