TY - JOUR
T1 - Clinical and Biochemical Correlates of Serum L-Ergothioneine Concentrations in Community-Dwelling Middle-Aged and Older Adults
AU - Sotgia, Salvatore
AU - Zinellu, Angelo
AU - Mangoni, Arduino
AU - Pinto, Gianfranco
AU - Attia, John
AU - Carru, Ciriaco
AU - McEvoy, Mark
PY - 2014/1/2
Y1 - 2014/1/2
N2 - Background: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults. Methods: Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study. Results: Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 μmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) μmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = 20.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = 20.13; P = 0.0063). Conclusions: A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.
AB - Background: Despite the increasing interest towards the biological role of L-ergothioneine, little is known about the serum concentrations of this unusual aminothiol in older adults. We addressed this issue in a representative sample of community-dwelling middle-aged and older adults. Methods: Body mass index, estimated glomerular filtration rate, serum concentrations of L-ergothioneine, taurine, homocysteine, cysteine, glutathione, cysteinylglycine, and glutamylcysteine were evaluated in 439 subjects (age 55-85 years) randomly selected from the Hunter Community Study. Results: Median L-ergothioneine concentration in the entire cohort was 1.01 IQR 0.78-1.33 μmol/L. Concentrations were not affected by gender (P = 0.41) or by presence of chronic medical conditions (P = 0.15). By considering only healthy subjects, we defined a reference interval for L-ergothioneine serum concentrations from 0.36 (90% CI 0.31-0.44) to 3.08 (90% CI 2.45-3.76) μmol/L. Using stepwise multiple linear regression analysis L-ergothioneine was negatively correlated with age (rpartial = 20.15; P = 0.0018) and with glutamylcysteine concentrations (rpartial = 20.13; P = 0.0063). Conclusions: A thorough analysis of serum L-ergothioneine concentrations was performed in a large group of community-dwelling middle-aged and older adults. Reference intervals were established. Age and glutamylcysteine were independently negatively associated with L-ergothioneine serum concentration.
UR - http://www.scopus.com/inward/record.url?scp=84894286988&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0084918
DO - 10.1371/journal.pone.0084918
M3 - Article
VL - 9
SP - e84918
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 1
M1 - e84918
ER -