Clinical and laboratory characteristics of 19 patients with Churg-Strauss syndrome from a single South Australian centre.

Andrew Whyte, WILLIAM SMITH, Swati Sinkar, Frank Kette, Pravin Hissaria

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Background: Churg-Strauss syndrome (CSS) is a rare, idiopathic systemic vasculitis. There is emerging evidence of an association between the presence or absence of antineutrophil cytoplasmic antibodies (ANCA) and clinical phenotype. Thromboembolism is an increasingly recognised complication of the disease. Aims: Given the paucity of Australian data, the aim of this study was to examine the clinical and laboratory features of CSS in a single Australian centre. Methods: We performed a retrospective review of all patients who fulfilled the American College of Rheumatology classification criteria for CSS managed at the Department of Immunology, Royal Adelaide Hospital between 2002 and 2008. Results: Nineteen patients were included. All patients had asthma and most had upper airway involvement. Peripheral nerve, musculoskeletal, gastrointestinal and cutaneous involvement was common. Renal and cardiac involvement was uncommon in this series. Histological confirmation was obtained in 15 patients (78.9%). Ten patients (52.6%) were ANCA+, and these were more likely to have musculoskeletal involvement, such as arthralgia or myalgia (odds ratio 57, P = 0.005). Thrombosis was a feature at diagnosis in six patients (31.6%); two of these recurred with relapse. Sixteen patients (84.2%) were followed up; five died, and mean survival was 8.9 years. Conclusions: This is the first Australian study to focus on CSS. Our results demonstrate similar presentation and prognosis of CSS to previous descriptions; however, we noted that musculoskeletal involvement was more common in ANCA+ patients. In our series, thrombosis was a significant complication and we suggest that thromboprophylaxis may be warranted.

    Original languageEnglish
    Pages (from-to)784-790
    Number of pages7
    JournalInternal Medicine Journal
    Issue number7
    Publication statusPublished - Jul 2013


    • Antineutrophil cytoplasmic antibody
    • Churg-Strauss syndrome
    • Epidemiology
    • Thrombosis
    • Vasculitis


    Dive into the research topics of 'Clinical and laboratory characteristics of 19 patients with Churg-Strauss syndrome from a single South Australian centre.'. Together they form a unique fingerprint.

    Cite this