Clinical outcomes of vitamin D deficiency and supplementation in cancer patients

Laisa Teleni, Jacqueline Baker, Bogda Koczwara, Michael Kimlin, E Walpole, Kathy Tsai, Elisabeth Isenring

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    29 Citations (Scopus)


    Results of recent studies suggest that circulating levels of vitamin D may play an important role in cancer-specific outcomes. The present systematic review was undertaken to determine the prevalence of vitamin D deficiency (<25nmol/L) and insufficiency (25-50nmol/L) in cancer patients and to evaluate the association between circulating calcidiol (the indicator of vitamin D status) and clinical outcomes. A systematic search of original, peer-reviewed studies on calcidiol at cancer diagnosis, and throughout treatment and survival, was conducted yielding 4,706 studies. A total of 37 studies met the inclusion criteria for this review. Reported mean blood calcidiol levels ranged from 24.7 to 87.4nmol/L, with up to 31% of patients identified as deficient and 67% as insufficient. The efficacy of cholecalciferol supplementation for raising the concentration of circulating calcidiol is unclear; standard supplement regimens of <1,000IU D3/day may not be sufficient to maintain adequate concentrations or prevent decreasing calcidiol. Dose-response studies linking vitamin D status to musculoskeletal and survival outcomes in cancer patients are lacking.

    Original languageEnglish
    Pages (from-to)611-621
    Number of pages11
    JournalNutrition Reviews
    Issue number9
    Publication statusPublished - Sept 2013


    • 25-hydroxyvitamin D
    • Cancer
    • Cancer-specific outcomes
    • Cholecalciferol
    • Vitamin D deficiency


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