Clinical pharmacology of GP53,633-a new non-steroidal anti-inflammatory drug - in patients with rheumatoid arthritis

S. Wanwimolruk; D. Thomas; D. J. Birkett; J. O. Miners; P. M. Brooks

doi:10.1007/BF01972382

Clinical pharmacology of GP53,633-a new non-steroidal anti-inflammatory drug - in patients with rheumatoid arthritis

S. Wanwimolruk
, D. Thomas
, D. J. Birkett
, J. O. Miners
, P. M. Brooks

Research output: Contribution to journal › Review article › peer-review

Abstract

GP53,633 is a new basic non-steroidal anti-inflammatory drug showing analgesic and anti-inflammatory activity in animal models. Pharmacokinetic studies in 6 patients with rheumatoid arthritis show it to be rapidly absorbed with a short half life (approximately 2 hours). No change in pharmacokinetics is seen over a two week treatment period. Clinical parameters of inflammation were reduced and no adverse reactions were seen.

Original language	English
Pages (from-to)	424-427
Number of pages	4
Journal	Agents and Actions
Volume	15
Issue number	3-4
DOIs	https://doi.org/10.1007/BF01972382
Publication status	Published - 1 Oct 1984

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title = "Clinical pharmacology of GP53,633-a new non-steroidal anti-inflammatory drug - in patients with rheumatoid arthritis",

abstract = "GP53,633 is a new basic non-steroidal anti-inflammatory drug showing analgesic and anti-inflammatory activity in animal models. Pharmacokinetic studies in 6 patients with rheumatoid arthritis show it to be rapidly absorbed with a short half life (approximately 2 hours). No change in pharmacokinetics is seen over a two week treatment period. Clinical parameters of inflammation were reduced and no adverse reactions were seen.",

author = "S. Wanwimolruk and D. Thomas and Birkett, \{D. J.\} and Miners, \{J. O.\} and Brooks, \{P. M.\}",

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AU - Wanwimolruk, S.

AU - Thomas, D.

AU - Birkett, D. J.

AU - Miners, J. O.

AU - Brooks, P. M.

PY - 1984/10/1

Y1 - 1984/10/1

N2 - GP53,633 is a new basic non-steroidal anti-inflammatory drug showing analgesic and anti-inflammatory activity in animal models. Pharmacokinetic studies in 6 patients with rheumatoid arthritis show it to be rapidly absorbed with a short half life (approximately 2 hours). No change in pharmacokinetics is seen over a two week treatment period. Clinical parameters of inflammation were reduced and no adverse reactions were seen.

AB - GP53,633 is a new basic non-steroidal anti-inflammatory drug showing analgesic and anti-inflammatory activity in animal models. Pharmacokinetic studies in 6 patients with rheumatoid arthritis show it to be rapidly absorbed with a short half life (approximately 2 hours). No change in pharmacokinetics is seen over a two week treatment period. Clinical parameters of inflammation were reduced and no adverse reactions were seen.

UR - https://www.scopus.com/pages/publications/0021746051

U2 - 10.1007/BF01972382

DO - 10.1007/BF01972382

M3 - Review article

C2 - 6524529

AN - SCOPUS:0021746051

SN - 0065-4299

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EP - 427

JO - Agents and Actions

JF - Agents and Actions

IS - 3-4

ER -

Clinical pharmacology of GP53,633-a new non-steroidal anti-inflammatory drug - in patients with rheumatoid arthritis

Abstract

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