Clinical Significance of Patients Presenting with Isolated Subsegmental Pulmonary Embolism at Two Tertiary Hospitals in Australia

Research output: Contribution to conferencePosterpeer-review


Aims: There is a clinical equipoise regarding the management of patients with isolated-subsegmental-pulmonary-embolism (SSPE). This study compared clinical outcomes of hospitalised patients with SSPE diagnosed on computed-tomography-pulmonary-angiogram (CTPA) with those with a more proximal pulmonary embolism (PE).

Methods: All patients with a positive CTPA for PE admitted between 2017-2021 at two tertiary hospitals in Australia were included in this study. Patients with an Isolated SSPE, defined as single or multiple filling defects localised at the level of subsegmental pulmonary arteries, were compared to those with a more proximal PE. The primary outcome was the cumulative incidence of recurrent venous thromboembolism (VTE) within 3 months and 1 year following the date of index event. The secondary outcome was overall mortality at 1 year of index event for the two groups. Competing risk analysis and Cox-proportional hazard models were used to compare VTE risk and mortality among patients with SSPE compared to those with proximal PE.

Results: Of 334 patients with a positive CTPA for PE, 111 (33.2%) had isolated SSPE. The mean (SD) age was 64.3 (17.7) years, 50.9% were males and 9.6% were identified as frail. The clinical presentation of PE was similar between the two groups, apart from history of dyspnoea which was less common among patients with isolated SSPE when compared to more proximal PE (P=0.026). Between patients with isolated SSPE and those with a more proximal PE, the risk of recurrent VTE within 3-months (0.9% vs. 1.8%, P=.458) and within 1-year of follow-up (2.7% vs. 6.3%, P=.126) did not differ significantly. Similarly, mortality within 1 year of index event was also not different between the two groups (Hazard ratio (HR) 1.72, 95% CI 0.92-3.21, P>0.05)

Conclusions: The prevalence of SSPE was 33.2% and these patients had clinical outcomes that did not differ from those with proximal PE.
Original languageEnglish
Number of pages1
Publication statusPublished - 28 Feb 2024
EventIMSANZ'24 - New Plymouth, New Plymouth, New Zealand
Duration: 28 Feb 20241 Mar 2024


Country/TerritoryNew Zealand
CityNew Plymouth
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Bibliographical note

Poster presentation, Thursday February 29, 2024, 12:45 pm - 1:15 pm.


  • Pulmonary embolism (PE)
  • Isolated subsegmental pulmonary embolism (SSPE)
  • Patients


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