TY - JOUR
T1 - Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD
T2 - present and future
AU - Zinellu, Angelo
AU - Zinellu, Elisabetta
AU - Mangoni, Arduino A.
AU - Pau, Maria Carmina
AU - Carru, Ciriaco
AU - Pirina, Pietro
AU - Fois, Alessandro G.
PY - 2022/12/31
Y1 - 2022/12/31
N2 - Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a leading cause of hospitalisation and death in COPD patients. In addition to the identification of better strategies to prevent AECOPD, there is an intense focus on discovering novel markers of disease severity that enhance risk stratification on hospital admission for the targeted institution of aggressive versus supportive treatments. In the quest for such biomarkers, an increasing body of evidence suggests that specific indexes derived from routine complete blood counts, i.e. the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), can significantly predict adverse outcomes in AECOPD. This narrative review discusses the current evidence regarding the association between the NLR and the PLR on admission and several clinical end-points (need for invasive ventilation, noninvasive mechanical ventilation failure, admission to an intensive care unit, pulmonary hypertension, length of hospitalisation, and mortality) in AECOPD. Future research directions and potential clinical applications of these haematological indexes in this patient group are also discussed.
AB - Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a leading cause of hospitalisation and death in COPD patients. In addition to the identification of better strategies to prevent AECOPD, there is an intense focus on discovering novel markers of disease severity that enhance risk stratification on hospital admission for the targeted institution of aggressive versus supportive treatments. In the quest for such biomarkers, an increasing body of evidence suggests that specific indexes derived from routine complete blood counts, i.e. the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), can significantly predict adverse outcomes in AECOPD. This narrative review discusses the current evidence regarding the association between the NLR and the PLR on admission and several clinical end-points (need for invasive ventilation, noninvasive mechanical ventilation failure, admission to an intensive care unit, pulmonary hypertension, length of hospitalisation, and mortality) in AECOPD. Future research directions and potential clinical applications of these haematological indexes in this patient group are also discussed.
KW - Acute exacerbations of chronic obstructive pulmonary disease
KW - AECOPD
KW - chronic obstructive pulmonary disease
KW - COPD
UR - http://www.scopus.com/inward/record.url?scp=85141072863&partnerID=8YFLogxK
U2 - 10.1183/16000617.0095-2022
DO - 10.1183/16000617.0095-2022
M3 - Review article
C2 - 36323421
AN - SCOPUS:85141072863
SN - 0905-9180
VL - 31
JO - European Respiratory Review
JF - European Respiratory Review
IS - 166
M1 - 220095
ER -