Abstract
AD7C-NTP (neural thread protein) is a ≈41-KD brain protein that is selectively elevated in Alzheimer disease (AD). AD7C-NTP is associated with the pathologic charges of AD, and overexpression of the AD7C-NTP gene is associated with cell death similar to that found in the AD brain. A newly developed competitive ELISA (enzyme-linked immunosorbent assay: was tested in urine samples from patients with AD, patients with non AD dementia, and healthy normal individuals. Mean assay measurement in the AD group (30.1 ± 10.8) was significantly higher than in the non-AD dementia control group (13.4 ± 3.4) and in the nondementia control group (14.8 ± 5.2) (P <.001). Mean assay measurement in early-AD cases (25.3 ± 7.6) was significantly lower than in other AD cases (33.9 ± 11.4). Levels of more than 18 units were found in 89% of overall AD cases and in 10% of overall controls. The results further validate ulnary AD7C-NTP as a biochemical marker for AD and indicate that the competitive ELISA-formal AD7C-NTP test in urine as an accurate method for determining AD7C-NTP levels in AD.
| Original language | English |
|---|---|
| Pages (from-to) | 2-8 |
| Number of pages | 7 |
| Journal | Neurology and Clinical Neurophysiology |
| Volume | 2002 |
| DOIs | |
| Publication status | Published - 2002 |
| Externally published | Yes |
Keywords
- Antibodies
- Botulinum toxin type A (BoNT/A)
- Cervical dystonia (CD)
- Therapy
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