Clinical Trials of Topical Interferon Therapy of Ulcerative Viral Keratitis

Barrie R. Jones, D. J. Coster, M. G. Falcon

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

An open trial suggested that monkey interferon had a therapeutic effect on ulcerative vaccinial keratitis in humans. A randomized, double-blind, placebo-controlled trial of either monkey interferon or drops of idoxuridine (given hourly by day and at 2-hr intervals by night for three days) suggested a therapeutic effect from idoxuridine but not from monkey interferon. Results of experiments with rabbits suggested that a daily application of human interferon (1.1 x 107international units/ml) would be effective in the prevention of herpetic ulcers but might not affect established lesions. Preliminary results are encouraging in a placebo-controlled, randomized trial of human interferon given once daily for seven days for prevention of recrudescence of epithelial herpetic lesions after minimal wiping debridement with a cotton-tipped swab. The design of the trial is closely analogous to that of the experiments with rabbits and permits ethically acceptable, placebo-controlled trials of antiviral agents.

Original languageEnglish
Pages (from-to)A169-A172
Number of pages4
JournalJournal of Infectious Diseases
Volume133
Issue numberSupp 2
DOIs
Publication statusPublished - Jun 1976
Externally publishedYes

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