Clonidine withdrawal in hypertension: Changes in Blood-pressure and Plasma and Urinary Noradrenaline

J. L. Reid; H. J. Dargie; D. S. Davies; L. M.H. Wing; C. A. Hamilton; C. T. Dollery

doi:10.1016/S0140-6736(77)92715-5

Clonidine withdrawal in hypertension: Changes in Blood-pressure and Plasma and Urinary Noradrenaline

J. L. Reid, H. J. Dargie, D. S. Davies, L. M.H. Wing, C. A. Hamilton, C. T. Dollery

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Abstract

Treatment was interrupted abruptly in 6 hypertensive patients receiving clonidine 0·45-5·4 mg daily. Blood-pressure rose to pretreatment levels within 24-48 h of withdrawal and was accompanied by insomnia, headache, flushing, sweating, and apprehension. These symptoms began 18-20 h after the last dose of clonidine. Plasma-noradrenaline levels and urinary catecholamine excretion increased 24-72 h after withdrawal of clonidine. The subjective symptoms were most prominent in patients on higher doses (>1 mg/day) and in those who had previously been receiving treatment with other antihypertensive drugs. One patient on a very low daily dose (0·15 mg) of clonidine had no symptoms and no significant changes in blood-pressure or catecholamine production after drug withdrawal.

Original language	English
Pages (from-to)	1171-1174
Number of pages	4
Journal	The Lancet
Volume	309
Issue number	8023
DOIs	https://doi.org/10.1016/S0140-6736(77)92715-5
Publication status	Published - 4 Jun 1977
Externally published	Yes

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title = "Clonidine withdrawal in hypertension: Changes in Blood-pressure and Plasma and Urinary Noradrenaline",

abstract = "Treatment was interrupted abruptly in 6 hypertensive patients receiving clonidine 0·45-5·4 mg daily. Blood-pressure rose to pretreatment levels within 24-48 h of withdrawal and was accompanied by insomnia, headache, flushing, sweating, and apprehension. These symptoms began 18-20 h after the last dose of clonidine. Plasma-noradrenaline levels and urinary catecholamine excretion increased 24-72 h after withdrawal of clonidine. The subjective symptoms were most prominent in patients on higher doses (>1 mg/day) and in those who had previously been receiving treatment with other antihypertensive drugs. One patient on a very low daily dose (0·15 mg) of clonidine had no symptoms and no significant changes in blood-pressure or catecholamine production after drug withdrawal.",

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T2 - Changes in Blood-pressure and Plasma and Urinary Noradrenaline

AU - Reid, J. L.

AU - Dargie, H. J.

AU - Davies, D. S.

AU - Wing, L. M.H.

AU - Hamilton, C. A.

AU - Dollery, C. T.

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AB - Treatment was interrupted abruptly in 6 hypertensive patients receiving clonidine 0·45-5·4 mg daily. Blood-pressure rose to pretreatment levels within 24-48 h of withdrawal and was accompanied by insomnia, headache, flushing, sweating, and apprehension. These symptoms began 18-20 h after the last dose of clonidine. Plasma-noradrenaline levels and urinary catecholamine excretion increased 24-72 h after withdrawal of clonidine. The subjective symptoms were most prominent in patients on higher doses (>1 mg/day) and in those who had previously been receiving treatment with other antihypertensive drugs. One patient on a very low daily dose (0·15 mg) of clonidine had no symptoms and no significant changes in blood-pressure or catecholamine production after drug withdrawal.

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Clonidine withdrawal in hypertension: Changes in Blood-pressure and Plasma and Urinary Noradrenaline

Abstract

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