Clustering and Additive Effects of Nongenetic Risk Factors in Non-Autosomal-Dominant Degenerative and Vascular Young Onset Dementia

Monica Cations, Adrienne Withall, Lee-Fay Low, Kylie Radford, Julian Trollor, Henry Brodaty, Perminder Sachdev, Peter Gonski, Gerald Anthony Broe, Robert G. Cumming, Brian Draper

Research output: Contribution to journalArticle

Abstract

Introduction: Both genetic and nongenetic factors contribute to the risk profile of young onset dementia (YOD), but risk factors often cooccur. This matched case-control study examined whether nongenetic risk factors cluster together, to inform targeted prevention efforts. Methods: Ninety-six participants with non autosomal-dominant degenerative and/or vascular YOD and 175 controls were recruited to 2 Australian epidemiological studies. Risk exposure was retrospectively self-reported and/or informant-reported. Results: Each additional exposure increased the risk for YOD, though only where vascular dementia was included in the analysis. Cluster analysis identified 4 risk groups, one of which reported a high probability of exposure to all risks and a significantly higher risk for YOD.

Original languageEnglish
Number of pages7
JournalAlzheimer Disease and Associated Disorders
DOIs
Publication statusE-pub ahead of print - 2019
Externally publishedYes

Keywords

  • additive risk
  • cluster analysis
  • latent class analysis
  • risk
  • vascular risk factors
  • young onset dementia

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