Co-existence of immunoreactivity to neuropeptide Y and vasoactive intestinal peptide in non-noradrenergic axons innervating guinea pig cerebral arteries after sympathectomy

I. L. Gibbins, J. L. Morris

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    64 Citations (Scopus)

    Abstract

    We have used double-labelling immunofluorescence to examine the coexistence of immunoreactivity (IR) to neuropeptide Y (NPY), tyrosine hydroxylase (TH) and vasoactive intestinal peptide (VIP) in autonomic nervous innervating guinea pig cerebral arteries. In the rostral circle of Willis of control animals. NPY-IR was detected in 86% of axons with TH-IR (noradrenergic) and 18% of VIP-IR (non-noradrenergic) axons. No axons contained both VIP-IR. Ten to 12 days after bilateral removal of the superior cervical ganglia all TH-IR axons had disappeared. The density of VIP-IR axons was unchanged but now 70% of VIP-IR axons contained NPY-IR. These results show that NPY is not exclusively associated with noradrenergic axons in the cerebral vasculature. Furthermore, NPY levels in non-noradrenergic axons increased following sympathetic denervation.

    Original languageEnglish
    Pages (from-to)402-406
    Number of pages5
    JournalBrain Research
    Volume444
    Issue number2
    DOIs
    Publication statusPublished - 22 Mar 1988

    Keywords

    • Cerebral artery
    • Co-existence
    • Immunofluorescence
    • Neuropeptide Y
    • Sympathectomy
    • Vasoactive intestinal peptide

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