Co-localization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs

I. L. Gibbins, J. B. Furness, M. Costa, I. MacIntyre, C. J. Hillyard, S. Girgis

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    512 Citations (Scopus)

    Abstract

    Calcitonin gene-related peptide (CGRP) has been immunohistochemically co-localized with substance P (SP) in capsaicin-sensitive, varicose axons supplying the skin, viscera and cardiovascular system of the guinea pig. After treatment with colchicine in vitro, 82% of SP neurons in the dorsal root ganglia contained CGRP-like immunoreactivity while 96% of CGRP neurons were immunoreactive for SP. Both CGRP- and SP-like immunoreactive material are transported peripherally and centrally from dorsal root ganglia. Thus, in tissues such as the gut where there are intrinsic nerves containing SP but lacking CGRP, CGRP-like immunoreactivity is a useful means of specifically labelling axons of most sensory neurons containing SP.

    Original languageEnglish
    Pages (from-to)125-130
    Number of pages6
    JournalNeuroscience letters
    Volume57
    Issue number2
    DOIs
    Publication statusPublished - 12 Jun 1985

    Keywords

    • calcitonin gene-related peptide
    • co-localization
    • guinea pig
    • immunohistochemistry
    • sensory nerves
    • substance P

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