Abstract
Calcitonin gene-related peptide (CGRP) has been immunohistochemically co-localized with substance P (SP) in capsaicin-sensitive, varicose axons supplying the skin, viscera and cardiovascular system of the guinea pig. After treatment with colchicine in vitro, 82% of SP neurons in the dorsal root ganglia contained CGRP-like immunoreactivity while 96% of CGRP neurons were immunoreactive for SP. Both CGRP- and SP-like immunoreactive material are transported peripherally and centrally from dorsal root ganglia. Thus, in tissues such as the gut where there are intrinsic nerves containing SP but lacking CGRP, CGRP-like immunoreactivity is a useful means of specifically labelling axons of most sensory neurons containing SP.
Original language | English |
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Pages (from-to) | 125-130 |
Number of pages | 6 |
Journal | Neuroscience letters |
Volume | 57 |
Issue number | 2 |
DOIs | |
Publication status | Published - 12 Jun 1985 |
Keywords
- calcitonin gene-related peptide
- co-localization
- guinea pig
- immunohistochemistry
- sensory nerves
- substance P