Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis

David L Newman; Stephen L. Gregory

doi:10.3390/ijms20184611

Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis

David L Newman, Stephen L. Gregory

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

29 Downloads (Pure)

Abstract

Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes

Original language	English
Article number	4611
Number of pages	15
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	18
DOIs	https://doi.org/10.3390/ijms20184611
Publication status	Published - 2 Sept 2019

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

aneuploidy
DNA damage
glycolysis
metabolism
oxidative stress
reactive oxygen species
Oxidative stress
Reactive oxygen species
Glycolysis
Aneuploidy
Metabolism

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10.3390/ijms20184611Licence: CC BY

Gregory_Cooperation_P2019Final published version, 1.41 MBLicence: CC BY

Cite this

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title = "Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis",

abstract = "Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes",

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AU - Gregory, Stephen L.

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N2 - Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes

AB - Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes

KW - aneuploidy

KW - DNA damage

KW - glycolysis

KW - metabolism

KW - oxidative stress

KW - reactive oxygen species

KW - Oxidative stress

KW - Reactive oxygen species

KW - Glycolysis

KW - Aneuploidy

KW - Metabolism

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M3 - Review article

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis

Abstract

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Keywords

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