Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis

David L Newman, Stephen L. Gregory

Research output: Contribution to journalReview article

1 Citation (Scopus)
1 Downloads (Pure)

Abstract

Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes
Original languageEnglish
Article number4611
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume20
Issue number18
DOIs
Publication statusPublished - 18 Sep 2019

Bibliographical note

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

  • aneuploidy
  • DNA damage
  • glycolysis
  • metabolism
  • oxidative stress
  • reactive oxygen species

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