Abstract
Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes
Original language | English |
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Article number | 4611 |
Number of pages | 15 |
Journal | International Journal of Molecular Sciences |
Volume | 20 |
Issue number | 18 |
DOIs | |
Publication status | Published - 2 Sept 2019 |
Bibliographical note
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Keywords
- aneuploidy
- DNA damage
- glycolysis
- metabolism
- oxidative stress
- reactive oxygen species
- Oxidative stress
- Reactive oxygen species
- Glycolysis
- Aneuploidy
- Metabolism