Co-regulation of phenytoin and tolbutamide metabolism in humans

W. Tassaneeyakul; M. E. Veronese; D. J. Birkett; C. J. Doecke; M. E. McManus; L. N. Sansom; J. O. Miners

Co-regulation of phenytoin and tolbutamide metabolism in humans

W. Tassaneeyakul, M. E. Veronese, D. J. Birkett, C. J. Doecke, M. E. McManus, L. N. Sansom, J. O. Miners

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

The disposition of phenytoin and tolbutamide was compared in eighteen healthy young adults separately administered single therapeutic doses (sodium phenytoin 300 mg, tolbutamide 500 mg) of the two drugs. Within the group, ratios of ranges of total and unbound areas under the plasma concentration-time curves were similar for both drugs. There were significant (P < 0.001) correlations between total (r = 0.88) and unbound (r = 0.86) areas under the plasma phenytoin and tolbutamide concentration-time curves. The results are consistent with the involvement of the same cytochrome P-450 isoenzyme(s) in the metabolism of tolbutamide and phenytoin.

Original language	English
Pages (from-to)	494-498
Number of pages	5
Journal	British Journal of Clinical Pharmacology
Volume	34
Issue number	6
Publication status	Published - 1 Jan 1992
Externally published	Yes

Keywords

co-regulation
cytochrome P-450
drug metabolism
phenytoin
tolbutamide

Access to Document

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1381450/pdf/brjclinpharm00039-0032.pdfLicence: In Copyright

Cite this

@article{c386f516a59b4caebf0b8c1373b59f23,

title = "Co-regulation of phenytoin and tolbutamide metabolism in humans",

abstract = "The disposition of phenytoin and tolbutamide was compared in eighteen healthy young adults separately administered single therapeutic doses (sodium phenytoin 300 mg, tolbutamide 500 mg) of the two drugs. Within the group, ratios of ranges of total and unbound areas under the plasma concentration-time curves were similar for both drugs. There were significant (P < 0.001) correlations between total (r = 0.88) and unbound (r = 0.86) areas under the plasma phenytoin and tolbutamide concentration-time curves. The results are consistent with the involvement of the same cytochrome P-450 isoenzyme(s) in the metabolism of tolbutamide and phenytoin.",

keywords = "co-regulation, cytochrome P-450, drug metabolism, phenytoin, tolbutamide",

author = "W. Tassaneeyakul and Veronese, {M. E.} and Birkett, {D. J.} and Doecke, {C. J.} and McManus, {M. E.} and Sansom, {L. N.} and Miners, {J. O.}",

year = "1992",

month = jan,

day = "1",

language = "English",

volume = "34",

pages = "494--498",

journal = "British Journal of Clinical Pharmacology",

issn = "0306-5251",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Co-regulation of phenytoin and tolbutamide metabolism in humans

AU - Tassaneeyakul, W.

AU - Veronese, M. E.

AU - Birkett, D. J.

AU - Doecke, C. J.

AU - McManus, M. E.

AU - Sansom, L. N.

AU - Miners, J. O.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - The disposition of phenytoin and tolbutamide was compared in eighteen healthy young adults separately administered single therapeutic doses (sodium phenytoin 300 mg, tolbutamide 500 mg) of the two drugs. Within the group, ratios of ranges of total and unbound areas under the plasma concentration-time curves were similar for both drugs. There were significant (P < 0.001) correlations between total (r = 0.88) and unbound (r = 0.86) areas under the plasma phenytoin and tolbutamide concentration-time curves. The results are consistent with the involvement of the same cytochrome P-450 isoenzyme(s) in the metabolism of tolbutamide and phenytoin.

AB - The disposition of phenytoin and tolbutamide was compared in eighteen healthy young adults separately administered single therapeutic doses (sodium phenytoin 300 mg, tolbutamide 500 mg) of the two drugs. Within the group, ratios of ranges of total and unbound areas under the plasma concentration-time curves were similar for both drugs. There were significant (P < 0.001) correlations between total (r = 0.88) and unbound (r = 0.86) areas under the plasma phenytoin and tolbutamide concentration-time curves. The results are consistent with the involvement of the same cytochrome P-450 isoenzyme(s) in the metabolism of tolbutamide and phenytoin.

KW - co-regulation

KW - cytochrome P-450

KW - drug metabolism

KW - phenytoin

KW - tolbutamide

UR - http://www.scopus.com/inward/record.url?scp=0026460228&partnerID=8YFLogxK

M3 - Article

C2 - 1493081

AN - SCOPUS:0026460228

SN - 0306-5251

VL - 34

SP - 494

EP - 498

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 6

ER -

Co-regulation of phenytoin and tolbutamide metabolism in humans

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this