Co-regulation of phenytoin and tolbutamide metabolism in humans

W. Tassaneeyakul, M. E. Veronese, D. J. Birkett, C. J. Doecke, M. E. McManus, L. N. Sansom, J. O. Miners

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50 Citations (Scopus)

Abstract

The disposition of phenytoin and tolbutamide was compared in eighteen healthy young adults separately administered single therapeutic doses (sodium phenytoin 300 mg, tolbutamide 500 mg) of the two drugs. Within the group, ratios of ranges of total and unbound areas under the plasma concentration-time curves were similar for both drugs. There were significant (P < 0.001) correlations between total (r = 0.88) and unbound (r = 0.86) areas under the plasma phenytoin and tolbutamide concentration-time curves. The results are consistent with the involvement of the same cytochrome P-450 isoenzyme(s) in the metabolism of tolbutamide and phenytoin.

Original languageEnglish
Pages (from-to)494-498
Number of pages5
JournalBritish Journal of Clinical Pharmacology
Volume34
Issue number6
Publication statusPublished - 1 Jan 1992
Externally publishedYes

Keywords

  • co-regulation
  • cytochrome P-450
  • drug metabolism
  • phenytoin
  • tolbutamide

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