Cochrane in context: Pharmacological interventions for hypertension in children

Swasti Chaturvedi, Deborah Lipszyc, Christoph Licht, Jonathan Craig, Rulan Parekh

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Background Hypertension is a major risk factor for stroke, coronary artery disease and kidney damage in adults. There is a paucity of data on the long-term sequelae of persistent hypertension in children, but it is known that children with hypertension have evidence of end-organ damage and are at risk of hypertension into adulthood. The prevalence of hypertension in children is increasing, most likely owing to a concurrent rise in obesity. In children with hypertension, nonpharmacological measures are often recommended as first-line therapy, but a significant proportion of children will eventually require pharmacological treatment to reduce blood pressure, especially those with evidence of end-organ damage at presentation or during follow-up. A systematic review of the effects of antihypertensive agents in children has not previously been conducted.

Original languageEnglish
Pages (from-to)581-583
Number of pages3
JournalEvidence-Based Child Health
Issue number3
Publication statusPublished - 19 Sep 2014
Externally publishedYes


  • hypertension
  • paediatric
  • clinical trials
  • medications
  • drugs
  • drugsmeta-analysis

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