Cognitive function among women with breast cancer receiving endocrine therapy: what are the impacts?

Joanna E. Fardell, Adam Walker, Raymond J. Chan, Janette L. Vardy

Research output: Contribution to journalEditorial

51 Downloads (Pure)

Abstract

Endocrine therapy (ET) is well established as a treatment in hormone-sensitive breast cancers, which account for approximately 75% of breast cancers. Commonly used endocrine treatments include selective estrogen receptor (ER) modulators (eg, tamoxifen), selective ER degraders (eg, fulvestrant), aromatase inhibitors (AIs; eg, letrozole, anastrozole, exemestane), and ovarian function suppression (eg, goserelin). There is strong evidence to support AIs as the preferred adjuvant treatment for postmenopausal women with ER–positive (ER+) breast cancer, with reductions in breast cancer recurrence and mortality compared with women receiving tamoxifen. Options for premenopausal women are tamoxifen or an AI with ovarian suppression.

Despite the benefits of ET on disease recurrence and mortality, many women discontinue treatment early. Reasons for nonadherence are complex, but side effects, particularly arthralgias with AIs and hot flushes with tamoxifen, are common reasons given for discontinuation...
Original languageEnglish
Article numberpkad026
Number of pages3
JournalJNCI Cancer Spectrum
Volume7
Issue number2
Early online date25 Mar 2023
DOIs
Publication statusPublished - Apr 2023

Keywords

  • Endocrine therapy (ET)
  • Breast cancer
  • Patient outcomes

Fingerprint

Dive into the research topics of 'Cognitive function among women with breast cancer receiving endocrine therapy: what are the impacts?'. Together they form a unique fingerprint.

Cite this