Colonic Response to Physiological, Chemical, Electrical and Mechanical Stimuli; What Can Be Used to Define Normal Motility?

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The colon plays an important functional role in the bacterial fermentation of carbohydrates, transmural exchange of fluid and short-chain fatty acids, and the formation, storage and evacuation of faeces and gaseous contents. Coordinated colonic motor patterns are essential for these functions to occur. Our understanding of human colonic motor patterns has largely come through the use of various forms of colonic manometry catheters, combined with a range of stimuli, both physiological and artificial. These stimuli are used in patients with colonic disorders such as constipation, irritable bowel syndrome and faecal incontinence to understand the pathophysiology mechanisms that may cause the disorder and/or the associated symptoms. However, our understanding of a “normal” colonic response remains poor. This review will assess our understanding of the normal colonic response to commonly used stimuli in short duration studies (
Original languageEnglish
Title of host publicationThe Enteric Nervous System II
EditorsNick J. Spencer, Marcello Costa, Stuart M. Brierley
Place of PublicationSwitzerland
PublisherSpringer
Chapter12
Pages125-132
Number of pages8
ISBN (Electronic)978-3-031-05843-1
ISBN (Print)978-3-031-05842-4
DOIs
Publication statusPublished - 2022

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1383
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Colon motility
  • Colonic manometry
  • Distension
  • Laxatives
  • Meal

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